Design, synthesis, in silico docking, ADMET and anticancer evaluations of thiazolidine-2,4-diones bearing heterocyclic rings as dual VEGFR-2/EGFR(T790M) tyrosine kinase inhibitors

Fourteen recent thiazolidine-2,4-diones bearing furan and/or thiophene heterocyclic rings have been designed, synthesized and assessed for their anticancer activities against four human tumor cell lines HepG2, A549, MCF-7 and HCT-116 targeting both VEGFR-2 and EGFR tyrosine kinases. Molecular design...

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Detalles Bibliográficos
Autores principales: Aziz, Nada A. A. M., George, Riham F., El-Adl, Khaled, Mahmoud, Walaa R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9045483/
https://www.ncbi.nlm.nih.gov/pubmed/35496328
http://dx.doi.org/10.1039/d2ra01119k

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9045483/
https://www.ncbi.nlm.nih.gov/pubmed/35496328
http://dx.doi.org/10.1039/d2ra01119k

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