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Aberrantly Expressed Small Noncoding RNAome in Keloid Skin Tissue
The skin is an organ that protects against injury and infection but can be damaged easily. Wound healing is a subtle balance which, if broken, can lead to keloid formation. Small noncoding (nc) RNAs can be of “housekeeping,” for example, ribosomal RNAs and transfer RNAs, or “regulatory,” for example...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9045488/ https://www.ncbi.nlm.nih.gov/pubmed/35495137 http://dx.doi.org/10.3389/fgene.2022.803083 |
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author | Yin, Chuang Wang, Chuandong Wang, Chen |
author_facet | Yin, Chuang Wang, Chuandong Wang, Chen |
author_sort | Yin, Chuang |
collection | PubMed |
description | The skin is an organ that protects against injury and infection but can be damaged easily. Wound healing is a subtle balance which, if broken, can lead to keloid formation. Small noncoding (nc) RNAs can be of “housekeeping,” for example, ribosomal RNAs and transfer RNAs, or “regulatory,” for example, microRNAs (miRNAs or miRs), small nucleolar RNAs (snoRNAs), and P-element–induced Wimpy testis (PIWI)-interacting RNA (piRNA) types. We examined five types of small ncRNAs [miR, piRNA, snoRNA, small nuclear (sn) RNA, and repeat-associated small interfering RNA (rasiRNA)] in keloid skin tissue (KST) using sequencing and real-time reverse transcription-quantitative polymerase chain reaction. All comparisons were made in relation to expression in normal skin tissue (obtained by abdominoplasty). The expression of three piRNAs was upregulated, and the expression of six piRNAs was downregulated in KST. The expression of 12 snoRNAs was upregulated, and the expression of two snoRNAs was downregulated in KST. The expression of two snRNAs was downregulated in KST. The expression of 18 miRs was upregulated, and the expression of three miRNAs was downregulated in KST. The expression of one rasiRNA was upregulated, and the expression of one rasiRNA was downregulated in KST. We revealed the differential expression of small ncRNAs in KST, which may aid the development of new treatment for keloids. |
format | Online Article Text |
id | pubmed-9045488 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-90454882022-04-28 Aberrantly Expressed Small Noncoding RNAome in Keloid Skin Tissue Yin, Chuang Wang, Chuandong Wang, Chen Front Genet Genetics The skin is an organ that protects against injury and infection but can be damaged easily. Wound healing is a subtle balance which, if broken, can lead to keloid formation. Small noncoding (nc) RNAs can be of “housekeeping,” for example, ribosomal RNAs and transfer RNAs, or “regulatory,” for example, microRNAs (miRNAs or miRs), small nucleolar RNAs (snoRNAs), and P-element–induced Wimpy testis (PIWI)-interacting RNA (piRNA) types. We examined five types of small ncRNAs [miR, piRNA, snoRNA, small nuclear (sn) RNA, and repeat-associated small interfering RNA (rasiRNA)] in keloid skin tissue (KST) using sequencing and real-time reverse transcription-quantitative polymerase chain reaction. All comparisons were made in relation to expression in normal skin tissue (obtained by abdominoplasty). The expression of three piRNAs was upregulated, and the expression of six piRNAs was downregulated in KST. The expression of 12 snoRNAs was upregulated, and the expression of two snoRNAs was downregulated in KST. The expression of two snRNAs was downregulated in KST. The expression of 18 miRs was upregulated, and the expression of three miRNAs was downregulated in KST. The expression of one rasiRNA was upregulated, and the expression of one rasiRNA was downregulated in KST. We revealed the differential expression of small ncRNAs in KST, which may aid the development of new treatment for keloids. Frontiers Media S.A. 2022-04-13 /pmc/articles/PMC9045488/ /pubmed/35495137 http://dx.doi.org/10.3389/fgene.2022.803083 Text en Copyright © 2022 Yin, Wang and Wang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Genetics Yin, Chuang Wang, Chuandong Wang, Chen Aberrantly Expressed Small Noncoding RNAome in Keloid Skin Tissue |
title | Aberrantly Expressed Small Noncoding RNAome in Keloid Skin Tissue |
title_full | Aberrantly Expressed Small Noncoding RNAome in Keloid Skin Tissue |
title_fullStr | Aberrantly Expressed Small Noncoding RNAome in Keloid Skin Tissue |
title_full_unstemmed | Aberrantly Expressed Small Noncoding RNAome in Keloid Skin Tissue |
title_short | Aberrantly Expressed Small Noncoding RNAome in Keloid Skin Tissue |
title_sort | aberrantly expressed small noncoding rnaome in keloid skin tissue |
topic | Genetics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9045488/ https://www.ncbi.nlm.nih.gov/pubmed/35495137 http://dx.doi.org/10.3389/fgene.2022.803083 |
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