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Lactate induces vascular permeability via disruption of VE-cadherin in endothelial cells during sepsis

Circulating lactate levels are a critical biomarker for sepsis and are positively correlated with sepsis-associated mortality. We investigated whether lactate plays a biological role in causing endothelial barrier dysfunction in sepsis. We showed that lactate causes vascular permeability and worsens...

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Detalles Bibliográficos
Autores principales:	Yang, Kun, Fan, Min, Wang, Xiaohui, Xu, Jingjing, Wang, Yana, Gill, P. Spencer, Ha, Tuanzhu, Liu, Li, Hall, Jennifer V., Williams, David L., Li, Chuanfu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2022
Materias:	Biomedicine and Life Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9045716/ https://www.ncbi.nlm.nih.gov/pubmed/35476437 http://dx.doi.org/10.1126/sciadv.abm8965

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