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Cryo-EM structure of the EBV ribonucleotide reductase BORF2 and mechanism of APOBEC3B inhibition

Viruses use a plethora of mechanisms to evade immune responses. A recent example is neutralization of the nuclear DNA cytosine deaminase APOBEC3B by the Epstein-Barr virus (EBV) ribonucleotide reductase subunit BORF2. Cryo-EM studies of APOBEC3B-BORF2 complexes reveal a large >1000-Å(2) binding s...

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Detalles Bibliográficos
Autores principales:	Shaban, Nadine M., Yan, Rui, Shi, Ke, Moraes, Sofia N., Cheng, Adam Z., Carpenter, Michael A., McLellan, Jason S., Yu, Zhiheng, Harris, Reuben S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2022
Materias:	Biomedicine and Life Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9045721/ https://www.ncbi.nlm.nih.gov/pubmed/35476445 http://dx.doi.org/10.1126/sciadv.abm2827

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