Cargando…
Paving the way towards effective plant-based inhibitors of hyaluronidase and tyrosinase: a critical review on a structure–activity relationship
Human has used plants to treat many civilisation diseases for thousands of years. Examples include reserpine (hypertension therapy), digoxin (myocardial diseases), vinblastine and vincristine (cancers), and opioids (palliative treatment). Plants are a rich source of natural metabolites with multiple...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9045780/ https://www.ncbi.nlm.nih.gov/pubmed/35470749 http://dx.doi.org/10.1080/14756366.2022.2061966 |
_version_ | 1784695389521182720 |
---|---|
author | Gębalski, Jakub Graczyk, Filip Załuski, Daniel |
author_facet | Gębalski, Jakub Graczyk, Filip Załuski, Daniel |
author_sort | Gębalski, Jakub |
collection | PubMed |
description | Human has used plants to treat many civilisation diseases for thousands of years. Examples include reserpine (hypertension therapy), digoxin (myocardial diseases), vinblastine and vincristine (cancers), and opioids (palliative treatment). Plants are a rich source of natural metabolites with multiple biological activities, and the use of modern approaches and tools allowed finally for more effective bioprospecting. The new phytochemicals are hyaluronidase (Hyal) inhibitors, which could serve as anti-cancer drugs, male contraceptives, and an antidote against venoms. In turn, tyrosinase inhibitors can be used in cosmetics/pharmaceuticals as whitening agents and to treat skin pigmentation disorders. However, the activity of these inhibitors is stricte dependent on their structure and the presence of the chemical groups, e.g. carbonyl or hydroxyl. This review aims to provide comprehensive and in-depth evidence related to the anti-tyrosinase and anti-Hyal activity of phytochemicals as well as confirming their efficiency and future perspectives. |
format | Online Article Text |
id | pubmed-9045780 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-90457802022-04-28 Paving the way towards effective plant-based inhibitors of hyaluronidase and tyrosinase: a critical review on a structure–activity relationship Gębalski, Jakub Graczyk, Filip Załuski, Daniel J Enzyme Inhib Med Chem Review Article Human has used plants to treat many civilisation diseases for thousands of years. Examples include reserpine (hypertension therapy), digoxin (myocardial diseases), vinblastine and vincristine (cancers), and opioids (palliative treatment). Plants are a rich source of natural metabolites with multiple biological activities, and the use of modern approaches and tools allowed finally for more effective bioprospecting. The new phytochemicals are hyaluronidase (Hyal) inhibitors, which could serve as anti-cancer drugs, male contraceptives, and an antidote against venoms. In turn, tyrosinase inhibitors can be used in cosmetics/pharmaceuticals as whitening agents and to treat skin pigmentation disorders. However, the activity of these inhibitors is stricte dependent on their structure and the presence of the chemical groups, e.g. carbonyl or hydroxyl. This review aims to provide comprehensive and in-depth evidence related to the anti-tyrosinase and anti-Hyal activity of phytochemicals as well as confirming their efficiency and future perspectives. Taylor & Francis 2022-04-26 /pmc/articles/PMC9045780/ /pubmed/35470749 http://dx.doi.org/10.1080/14756366.2022.2061966 Text en © 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Gębalski, Jakub Graczyk, Filip Załuski, Daniel Paving the way towards effective plant-based inhibitors of hyaluronidase and tyrosinase: a critical review on a structure–activity relationship |
title | Paving the way towards effective plant-based inhibitors of hyaluronidase and tyrosinase: a critical review on a structure–activity relationship |
title_full | Paving the way towards effective plant-based inhibitors of hyaluronidase and tyrosinase: a critical review on a structure–activity relationship |
title_fullStr | Paving the way towards effective plant-based inhibitors of hyaluronidase and tyrosinase: a critical review on a structure–activity relationship |
title_full_unstemmed | Paving the way towards effective plant-based inhibitors of hyaluronidase and tyrosinase: a critical review on a structure–activity relationship |
title_short | Paving the way towards effective plant-based inhibitors of hyaluronidase and tyrosinase: a critical review on a structure–activity relationship |
title_sort | paving the way towards effective plant-based inhibitors of hyaluronidase and tyrosinase: a critical review on a structure–activity relationship |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9045780/ https://www.ncbi.nlm.nih.gov/pubmed/35470749 http://dx.doi.org/10.1080/14756366.2022.2061966 |
work_keys_str_mv | AT gebalskijakub pavingthewaytowardseffectiveplantbasedinhibitorsofhyaluronidaseandtyrosinaseacriticalreviewonastructureactivityrelationship AT graczykfilip pavingthewaytowardseffectiveplantbasedinhibitorsofhyaluronidaseandtyrosinaseacriticalreviewonastructureactivityrelationship AT załuskidaniel pavingthewaytowardseffectiveplantbasedinhibitorsofhyaluronidaseandtyrosinaseacriticalreviewonastructureactivityrelationship |