Autoinhibition and regulation by phosphoinositides of ATP8B1, a human lipid flippase associated with intrahepatic cholestatic disorders

P4-ATPases flip lipids from the exoplasmic to the cytosolic leaflet, thus maintaining lipid asymmetry in eukaryotic cell membranes. Mutations in several human P4-ATPase genes are associated with severe diseases, for example in ATP8B1 causing progressive familial intrahepatic cholestasis, a rare inhe...

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Detalles Bibliográficos
Autores principales: Dieudonné, Thibaud, Herrera, Sara Abad, Laursen, Michelle Juknaviciute, Lejeune, Maylis, Stock, Charlott, Slimani, Kahina, Jaxel, Christine, Lyons, Joseph A, Montigny, Cédric, Pomorski, Thomas Günther, Nissen, Poul, Lenoir, Guillaume
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9045818/
https://www.ncbi.nlm.nih.gov/pubmed/35416773
http://dx.doi.org/10.7554/eLife.75272

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