Targeting HSP90 sensitizes pancreas carcinoma to PD-1 blockade

Interferon gamma (IFNG/IFNγ)-induced adaptive immune resistance remains a challenge for tumor therapy. We observed that the chaperone heat shock protein 90 (HSP90) stabilizes the transcription factor signal transducer and activator of transcription 1 (STAT1), resulting in IFNγ-induced expression of...

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Autores principales: Liu, Jiao, Kang, Rui, Kroemer, Guido, Tang, Daolin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Author’s View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9045827/
https://www.ncbi.nlm.nih.gov/pubmed/35496499
http://dx.doi.org/10.1080/2162402X.2022.2068488
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author Liu, Jiao
Kang, Rui
Kroemer, Guido
Tang, Daolin
author_facet Liu, Jiao
Kang, Rui
Kroemer, Guido
Tang, Daolin
author_sort Liu, Jiao
collection PubMed
description Interferon gamma (IFNG/IFNγ)-induced adaptive immune resistance remains a challenge for tumor therapy. We observed that the chaperone heat shock protein 90 (HSP90) stabilizes the transcription factor signal transducer and activator of transcription 1 (STAT1), resulting in IFNγ-induced expression of immunosuppressive indoleamine 2,3-dioxygenase 1 (IDO1) and programmed death-ligand 1 (PD-L1/CD274). Pharmacological inhibition of HSP90 enhances the efficacy of programmed cell death 1 (PDCD1/PD-1) targeting immunotherapy in suitable mouse models without any toxicity.
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spelling pubmed-90458272022-04-28 Targeting HSP90 sensitizes pancreas carcinoma to PD-1 blockade Liu, Jiao Kang, Rui Kroemer, Guido Tang, Daolin Oncoimmunology Author’s View Interferon gamma (IFNG/IFNγ)-induced adaptive immune resistance remains a challenge for tumor therapy. We observed that the chaperone heat shock protein 90 (HSP90) stabilizes the transcription factor signal transducer and activator of transcription 1 (STAT1), resulting in IFNγ-induced expression of immunosuppressive indoleamine 2,3-dioxygenase 1 (IDO1) and programmed death-ligand 1 (PD-L1/CD274). Pharmacological inhibition of HSP90 enhances the efficacy of programmed cell death 1 (PDCD1/PD-1) targeting immunotherapy in suitable mouse models without any toxicity. Taylor & Francis 2022-04-25 /pmc/articles/PMC9045827/ /pubmed/35496499 http://dx.doi.org/10.1080/2162402X.2022.2068488 Text en © 2022 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Author’s View
Liu, Jiao
Kang, Rui
Kroemer, Guido
Tang, Daolin
Targeting HSP90 sensitizes pancreas carcinoma to PD-1 blockade
title Targeting HSP90 sensitizes pancreas carcinoma to PD-1 blockade
title_full Targeting HSP90 sensitizes pancreas carcinoma to PD-1 blockade
title_fullStr Targeting HSP90 sensitizes pancreas carcinoma to PD-1 blockade
title_full_unstemmed Targeting HSP90 sensitizes pancreas carcinoma to PD-1 blockade
title_short Targeting HSP90 sensitizes pancreas carcinoma to PD-1 blockade
title_sort targeting hsp90 sensitizes pancreas carcinoma to pd-1 blockade
topic Author’s View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9045827/
https://www.ncbi.nlm.nih.gov/pubmed/35496499
http://dx.doi.org/10.1080/2162402X.2022.2068488
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