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Endothelial Cullin3 Mutation Impairs Nitric Oxide-Mediated Vasodilation and Promotes Salt-Induced Hypertension

Human hypertension caused by in-frame deletion of CULLIN3 exon-9 (Cul3∆9) is driven by renal and vascular mechanisms. We bred conditionally activatable Cul3∆9 transgenic mice with tamoxifen-inducible Tie2-CRE(ERT2) mice to test the importance of endothelial Cul3. The resultant mice (E-Cul3∆9) trende...

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Detalles Bibliográficos
Autores principales:	Wu, Jing, Fang, Shi, Lu, Ko-Ting, Kumar, Gaurav, Reho, John J, Brozoski, Daniel T, Otanwa, Adokole J, Hu, Chunyan, Nair, Anand R, Wackman, Kelsey K, Agbor, Larry N, Grobe, Justin L, Sigmund, Curt D
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9045850/ https://www.ncbi.nlm.nih.gov/pubmed/35493997 http://dx.doi.org/10.1093/function/zqac017

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