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Oxidative Stress and Ginsenosides: An Update on the Molecular Mechanisms
Ginsenosides are a class of active components extracted from ginseng plants (such as Panax ginseng, Panax quinquefolium, and Panax notoginseng). Ginsenosides have significant protective effects on the nervous system, cardiovascular system, and immune system, so they have been widely used in the trea...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9045968/ https://www.ncbi.nlm.nih.gov/pubmed/35498130 http://dx.doi.org/10.1155/2022/9299574 |
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author | He, Bo Chen, Deyun Zhang, Xiaochao Yang, Renhua Yang, Yuan Chen, Peng Shen, Zhiqiang |
author_facet | He, Bo Chen, Deyun Zhang, Xiaochao Yang, Renhua Yang, Yuan Chen, Peng Shen, Zhiqiang |
author_sort | He, Bo |
collection | PubMed |
description | Ginsenosides are a class of active components extracted from ginseng plants (such as Panax ginseng, Panax quinquefolium, and Panax notoginseng). Ginsenosides have significant protective effects on the nervous system, cardiovascular system, and immune system, so they have been widely used in the treatment of related diseases. Entry of a variety of endogenous or exogenous harmful substances into the body can lead to an imbalance between the antioxidant defense system and reactive oxygen species, thus producing toxic effects on a variety of tissues and cells. In addition, oxidative stress can alter multiple signaling pathways, including the Keap1/Nrf2/ARE, PI3K/AKT, Wnt/β-catenin, and NF-κB pathways. With the deepening of research in this field, various ginsenoside monomers have been reported to exert antioxidant effects through multiple signaling pathways and thus have good application prospects. This article summarized the research advancements regarding the antioxidative effects and related mechanisms of ginsenosides, providing a theoretical basis for experimental research on and clinical treatment with ginsenosides. |
format | Online Article Text |
id | pubmed-9045968 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-90459682022-04-28 Oxidative Stress and Ginsenosides: An Update on the Molecular Mechanisms He, Bo Chen, Deyun Zhang, Xiaochao Yang, Renhua Yang, Yuan Chen, Peng Shen, Zhiqiang Oxid Med Cell Longev Review Article Ginsenosides are a class of active components extracted from ginseng plants (such as Panax ginseng, Panax quinquefolium, and Panax notoginseng). Ginsenosides have significant protective effects on the nervous system, cardiovascular system, and immune system, so they have been widely used in the treatment of related diseases. Entry of a variety of endogenous or exogenous harmful substances into the body can lead to an imbalance between the antioxidant defense system and reactive oxygen species, thus producing toxic effects on a variety of tissues and cells. In addition, oxidative stress can alter multiple signaling pathways, including the Keap1/Nrf2/ARE, PI3K/AKT, Wnt/β-catenin, and NF-κB pathways. With the deepening of research in this field, various ginsenoside monomers have been reported to exert antioxidant effects through multiple signaling pathways and thus have good application prospects. This article summarized the research advancements regarding the antioxidative effects and related mechanisms of ginsenosides, providing a theoretical basis for experimental research on and clinical treatment with ginsenosides. Hindawi 2022-04-20 /pmc/articles/PMC9045968/ /pubmed/35498130 http://dx.doi.org/10.1155/2022/9299574 Text en Copyright © 2022 Bo He et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article He, Bo Chen, Deyun Zhang, Xiaochao Yang, Renhua Yang, Yuan Chen, Peng Shen, Zhiqiang Oxidative Stress and Ginsenosides: An Update on the Molecular Mechanisms |
title | Oxidative Stress and Ginsenosides: An Update on the Molecular Mechanisms |
title_full | Oxidative Stress and Ginsenosides: An Update on the Molecular Mechanisms |
title_fullStr | Oxidative Stress and Ginsenosides: An Update on the Molecular Mechanisms |
title_full_unstemmed | Oxidative Stress and Ginsenosides: An Update on the Molecular Mechanisms |
title_short | Oxidative Stress and Ginsenosides: An Update on the Molecular Mechanisms |
title_sort | oxidative stress and ginsenosides: an update on the molecular mechanisms |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9045968/ https://www.ncbi.nlm.nih.gov/pubmed/35498130 http://dx.doi.org/10.1155/2022/9299574 |
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