MicroRNA-10a/b inhibit TGF-β/Smad-induced renal fibrosis by targeting TGF-β receptor 1 in diabetic kidney disease

TGF-β/Smad signaling plays a vital role in the development of fibrosis in diabetic kidney disease (DKD). However, remedies targeting key elements in TGF-β/Smad signaling are lacking. Here, we found that TGF-β receptor 1 (TGFBR1), a key protein in TGF-β/Smad signaling, was upregulated in kidney from...

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Detalles Bibliográficos
Autores principales: Li, Jinxiang, Yue, Shuling, Fang, Jingwen, Zeng, Junling, Chen, Siqi, Tian, Jianwei, Nie, Sheng, Liu, Xiaoting, Ding, Hanying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9046110/
https://www.ncbi.nlm.nih.gov/pubmed/35505968
http://dx.doi.org/10.1016/j.omtn.2022.04.002

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