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YAP-dependent Wnt5a induction in hypertrophic adipocytes restrains adiposity

Wnt5a, a prototypic non-canonical Wnt, is an inflammatory factor elevated in the sera of obese humans and mice. In the present study, fat-specific knockout of Wnt5a (Wnt5a-FKO) prevented HFD-induced increases in serum Wnt5a levels in male C57BL/6 J mice, which suggested adipocytes are primarily resp...

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Detalles Bibliográficos
Autores principales:	Lee, Gwan-Jun, Kim, Youn Ju, Park, Bongju, Yim, Sujin, Park, Chansang, Roh, Hyunsoo, Moon, Yunwon, Seong, Je Kyung, Park, Hyunsung
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9046197/ https://www.ncbi.nlm.nih.gov/pubmed/35478181 http://dx.doi.org/10.1038/s41419-022-04847-0

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