BTB(BCL6) dimers as building blocks for reversible drug-induced protein oligomerization

Here, we characterize the BTB domain of the transcription factor BCL6 (BTB(BCL6)) as a small-molecule-controlled, reversible oligomerization switch, which oligomerizes upon BI-3802 treatment and de-oligomerizes upon addition of BI-3812. We show that the magnitude of oligomerization can be controlled...

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Detalles Bibliográficos
Autores principales: Nitsch, Lena, Jensen, Patrizia, Yoon, Hojong, Koeppel, Jonas, Burman, Shourya Sonkar Roy, Fischer, Eric Sebastian, Scholl, Claudia, Fröhling, Stefan, Słabicki, Mikołaj
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9046236/
https://www.ncbi.nlm.nih.gov/pubmed/35497498
http://dx.doi.org/10.1016/j.crmeth.2022.100193

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