Single-Cell Analysis Reveals Unexpected Cellular Changes and Transposon Expression Signatures in the Colonic Epithelium of Treatment-Naïve Adult Crohn’s Disease Patients

BACKGROUND & AIMS: The intestinal barrier comprises a monolayer of specialized intestinal epithelial cells (IECs) that are critical in maintaining mucosal homeostasis. Dysfunction within various IEC fractions can alter intestinal permeability in a genetically susceptible host, resulting in a chr...

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Detalles Bibliográficos
Autores principales: Kanke, Matt, Kennedy Ng, Meaghan M., Connelly, Sean, Singh, Manvendra, Schaner, Matthew, Shanahan, Michael T., Wolber, Elizabeth A., Beasley, Caroline, Lian, Grace, Jain, Animesh, Long, Millie D., Barnes, Edward L., Herfarth, Hans H., Isaacs, Kim L., Hansen, Jonathon J., Kapadia, Muneera, Guillem, Jose Gaston, Feschotte, Cedric, Furey, Terrence S., Sheikh, Shehzad Z., Sethupathy, Praveen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9046244/
https://www.ncbi.nlm.nih.gov/pubmed/35158099
http://dx.doi.org/10.1016/j.jcmgh.2022.02.005

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