Extrinsic KRAS Signaling Shapes the Pancreatic Microenvironment Through Fibroblast Reprogramming

BACKGROUND & AIMS: Oncogenic Kirsten Rat Sarcoma virus (KRAS) is the hallmark mutation of human pancreatic cancer and a driver of tumorigenesis in genetically engineered mouse models of the disease. Although the tumor cell–intrinsic effects of oncogenic Kras expression have been widely studied,...

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Detalles Bibliográficos
Autores principales: Velez-Delgado, Ashley, Donahue, Katelyn L., Brown, Kristee L., Du, Wenting, Irizarry-Negron, Valerie, Menjivar, Rosa E., Lasse Opsahl, Emily L., Steele, Nina G., The, Stephanie, Lazarus, Jenny, Sirihorachai, Veerin R., Yan, Wei, Kemp, Samantha B., Kerk, Samuel A., Bollampally, Murali, Yang, Sion, Scales, Michael K., Avritt, Faith R., Lima, Fatima, Lyssiotis, Costas A., Rao, Arvind, Crawford, Howard C., Bednar, Filip, Frankel, Timothy L., Allen, Benjamin L., Zhang, Yaqing, Pasca di Magliano, Marina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9046274/
https://www.ncbi.nlm.nih.gov/pubmed/35245687
http://dx.doi.org/10.1016/j.jcmgh.2022.02.016

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