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Enhanced biomedical applicability of ZrO(2)–SiO(2) ceramic composites in 3D printed bone scaffolds

Zirconia (ZrO(2)) has been widely used in clinical applications, such as bone and dental implantation, because of its favorable mechanical properties and resistance to fracture. However, the poor cell affinity of ZrO(2) for bone regeneration and tissue binding, as well as its shrinkage due to crysta...

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Autores principales: Chang, Chih-Hao, Lin, Chih-Yang, Chang, Chih-Hung, Liu, Fwu-Hsing, Huang, Yu-Tzu, Liao, Yunn-Shiuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9046279/
https://www.ncbi.nlm.nih.gov/pubmed/35477956
http://dx.doi.org/10.1038/s41598-022-10731-w
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author Chang, Chih-Hao
Lin, Chih-Yang
Chang, Chih-Hung
Liu, Fwu-Hsing
Huang, Yu-Tzu
Liao, Yunn-Shiuan
author_facet Chang, Chih-Hao
Lin, Chih-Yang
Chang, Chih-Hung
Liu, Fwu-Hsing
Huang, Yu-Tzu
Liao, Yunn-Shiuan
author_sort Chang, Chih-Hao
collection PubMed
description Zirconia (ZrO(2)) has been widely used in clinical applications, such as bone and dental implantation, because of its favorable mechanical properties and resistance to fracture. However, the poor cell affinity of ZrO(2) for bone regeneration and tissue binding, as well as its shrinkage due to crystal phase transformation during heat treatment, limits its clinical use and processing plasticity. This study aims to investigate an appropriate ZrO(2)–SiO(2) composite recipe for ceramic 3D printing processes that can strike a balance between the mechanical properties and cell affinity needed in clinical applications. Specimens with different ZrO(2)–SiO(2) composite recipes were fabricated by a selective laser gelling method and sintered at temperatures ranging from 900 to 1500 °C. The S5Z5 composite, which consists of 50 wt% ZrO(2), 35 wt% SiO(2) and 15 wt% SiO(2) sol, showed an appropriate compressive strength and bending strength of 82.56 MPa and 55.98 MPa, respectively, at a sintering temperature of 1300 °C. The shrinkage rate of the S5Z5 composite was approximately 5% when the sintering temperature was increased from 900 to 1500 °C. All composites exhibited no cytotoxicity after 144 h of MG63 cell incubation, and the S5Z5 composite exhibited the most obvious cell affinity among the composite recipes. From these results, compared with other composites, the S5Z5 composite was shown to possess mechanical properties and a cell affinity more comparable to those of natural human bone.
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spelling pubmed-90462792022-04-29 Enhanced biomedical applicability of ZrO(2)–SiO(2) ceramic composites in 3D printed bone scaffolds Chang, Chih-Hao Lin, Chih-Yang Chang, Chih-Hung Liu, Fwu-Hsing Huang, Yu-Tzu Liao, Yunn-Shiuan Sci Rep Article Zirconia (ZrO(2)) has been widely used in clinical applications, such as bone and dental implantation, because of its favorable mechanical properties and resistance to fracture. However, the poor cell affinity of ZrO(2) for bone regeneration and tissue binding, as well as its shrinkage due to crystal phase transformation during heat treatment, limits its clinical use and processing plasticity. This study aims to investigate an appropriate ZrO(2)–SiO(2) composite recipe for ceramic 3D printing processes that can strike a balance between the mechanical properties and cell affinity needed in clinical applications. Specimens with different ZrO(2)–SiO(2) composite recipes were fabricated by a selective laser gelling method and sintered at temperatures ranging from 900 to 1500 °C. The S5Z5 composite, which consists of 50 wt% ZrO(2), 35 wt% SiO(2) and 15 wt% SiO(2) sol, showed an appropriate compressive strength and bending strength of 82.56 MPa and 55.98 MPa, respectively, at a sintering temperature of 1300 °C. The shrinkage rate of the S5Z5 composite was approximately 5% when the sintering temperature was increased from 900 to 1500 °C. All composites exhibited no cytotoxicity after 144 h of MG63 cell incubation, and the S5Z5 composite exhibited the most obvious cell affinity among the composite recipes. From these results, compared with other composites, the S5Z5 composite was shown to possess mechanical properties and a cell affinity more comparable to those of natural human bone. Nature Publishing Group UK 2022-04-27 /pmc/articles/PMC9046279/ /pubmed/35477956 http://dx.doi.org/10.1038/s41598-022-10731-w Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Chang, Chih-Hao
Lin, Chih-Yang
Chang, Chih-Hung
Liu, Fwu-Hsing
Huang, Yu-Tzu
Liao, Yunn-Shiuan
Enhanced biomedical applicability of ZrO(2)–SiO(2) ceramic composites in 3D printed bone scaffolds
title Enhanced biomedical applicability of ZrO(2)–SiO(2) ceramic composites in 3D printed bone scaffolds
title_full Enhanced biomedical applicability of ZrO(2)–SiO(2) ceramic composites in 3D printed bone scaffolds
title_fullStr Enhanced biomedical applicability of ZrO(2)–SiO(2) ceramic composites in 3D printed bone scaffolds
title_full_unstemmed Enhanced biomedical applicability of ZrO(2)–SiO(2) ceramic composites in 3D printed bone scaffolds
title_short Enhanced biomedical applicability of ZrO(2)–SiO(2) ceramic composites in 3D printed bone scaffolds
title_sort enhanced biomedical applicability of zro(2)–sio(2) ceramic composites in 3d printed bone scaffolds
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9046279/
https://www.ncbi.nlm.nih.gov/pubmed/35477956
http://dx.doi.org/10.1038/s41598-022-10731-w
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