ASCL1 activates neuronal stem cell-like lineage programming through remodeling of the chromatin landscape in prostate cancer

Treatment with androgen receptor pathway inhibitors (ARPIs) in prostate cancer leads to the emergence of resistant tumors characterized by lineage plasticity and differentiation toward neuroendocrine lineage. Here, we find that ARPIs induce a rapid epigenetic alteration mediated by large-scale chrom...

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Detalles Bibliográficos
Autores principales: Nouruzi, Shaghayegh, Ganguli, Dwaipayan, Tabrizian, Nakisa, Kobelev, Maxim, Sivak, Olena, Namekawa, Takeshi, Thaper, Daksh, Baca, Sylvan C., Freedman, Matthew L., Aguda, Adeleke, Davies, Alastair, Zoubeidi, Amina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9046280/
https://www.ncbi.nlm.nih.gov/pubmed/35477723
http://dx.doi.org/10.1038/s41467-022-29963-5

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