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Receptor architecture of macaque and human early visual areas: not equal, but comparable

Existing cytoarchitectonic maps of the human and macaque posterior occipital cortex differ in the number of areas they display, thus hampering identification of homolog structures. We applied quantitative in vitro receptor autoradiography to characterize the receptor architecture of the primary visu...

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Autores principales: Rapan, Lucija, Niu, Meiqi, Zhao, Ling, Funck, Thomas, Amunts, Katrin, Zilles, Karl, Palomero-Gallagher, Nicola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9046358/
https://www.ncbi.nlm.nih.gov/pubmed/34931262
http://dx.doi.org/10.1007/s00429-021-02437-y
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author Rapan, Lucija
Niu, Meiqi
Zhao, Ling
Funck, Thomas
Amunts, Katrin
Zilles, Karl
Palomero-Gallagher, Nicola
author_facet Rapan, Lucija
Niu, Meiqi
Zhao, Ling
Funck, Thomas
Amunts, Katrin
Zilles, Karl
Palomero-Gallagher, Nicola
author_sort Rapan, Lucija
collection PubMed
description Existing cytoarchitectonic maps of the human and macaque posterior occipital cortex differ in the number of areas they display, thus hampering identification of homolog structures. We applied quantitative in vitro receptor autoradiography to characterize the receptor architecture of the primary visual and early extrastriate cortex in macaque and human brains, using previously published cytoarchitectonic criteria as starting point of our analysis. We identified 8 receptor architectonically distinct areas in the macaque brain (mV1d, mV1v, mV2d, mV2v, mV3d, mV3v, mV3A, mV4v), and their respective counterpart areas in the human brain (hV1d, hV1v, hV2d, hV2v, hV3d, hV3v, hV3A, hV4v). Mean densities of 14 neurotransmitter receptors were quantified in each area, and ensuing receptor fingerprints used for multivariate analyses. The 1st principal component segregated macaque and human early visual areas differ. However, the 2nd principal component showed that within each species, area-specific differences in receptor fingerprints were associated with the hierarchical processing level of each area. Subdivisions of V2 and V3 were found to cluster together in both species and were segregated from subdivisions of V1 and from V4v. Thus, comparative studies like this provide valuable architectonic insights into how differences in underlying microstructure impact evolutionary changes in functional processing of the primate brain and, at the same time, provide strong arguments for use of macaque monkey brain as a suitable animal model for translational studies. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00429-021-02437-y.
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spelling pubmed-90463582022-05-07 Receptor architecture of macaque and human early visual areas: not equal, but comparable Rapan, Lucija Niu, Meiqi Zhao, Ling Funck, Thomas Amunts, Katrin Zilles, Karl Palomero-Gallagher, Nicola Brain Struct Funct Original Article Existing cytoarchitectonic maps of the human and macaque posterior occipital cortex differ in the number of areas they display, thus hampering identification of homolog structures. We applied quantitative in vitro receptor autoradiography to characterize the receptor architecture of the primary visual and early extrastriate cortex in macaque and human brains, using previously published cytoarchitectonic criteria as starting point of our analysis. We identified 8 receptor architectonically distinct areas in the macaque brain (mV1d, mV1v, mV2d, mV2v, mV3d, mV3v, mV3A, mV4v), and their respective counterpart areas in the human brain (hV1d, hV1v, hV2d, hV2v, hV3d, hV3v, hV3A, hV4v). Mean densities of 14 neurotransmitter receptors were quantified in each area, and ensuing receptor fingerprints used for multivariate analyses. The 1st principal component segregated macaque and human early visual areas differ. However, the 2nd principal component showed that within each species, area-specific differences in receptor fingerprints were associated with the hierarchical processing level of each area. Subdivisions of V2 and V3 were found to cluster together in both species and were segregated from subdivisions of V1 and from V4v. Thus, comparative studies like this provide valuable architectonic insights into how differences in underlying microstructure impact evolutionary changes in functional processing of the primate brain and, at the same time, provide strong arguments for use of macaque monkey brain as a suitable animal model for translational studies. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00429-021-02437-y. Springer Berlin Heidelberg 2021-12-20 2022 /pmc/articles/PMC9046358/ /pubmed/34931262 http://dx.doi.org/10.1007/s00429-021-02437-y Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Article
Rapan, Lucija
Niu, Meiqi
Zhao, Ling
Funck, Thomas
Amunts, Katrin
Zilles, Karl
Palomero-Gallagher, Nicola
Receptor architecture of macaque and human early visual areas: not equal, but comparable
title Receptor architecture of macaque and human early visual areas: not equal, but comparable
title_full Receptor architecture of macaque and human early visual areas: not equal, but comparable
title_fullStr Receptor architecture of macaque and human early visual areas: not equal, but comparable
title_full_unstemmed Receptor architecture of macaque and human early visual areas: not equal, but comparable
title_short Receptor architecture of macaque and human early visual areas: not equal, but comparable
title_sort receptor architecture of macaque and human early visual areas: not equal, but comparable
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9046358/
https://www.ncbi.nlm.nih.gov/pubmed/34931262
http://dx.doi.org/10.1007/s00429-021-02437-y
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