Phospholipase A(2)-based probes to study vesicle trafficking

Vesicle exo- and endocytosis mediate important biological functions, including synaptic transmission. In this issue of Cell Reports Methods, Seong J. An et al. found that the fluorescently tagged C2 domain of phospholipase A(2) binds to membrane phosphatidylcholine and thus labels vesicle membrane,...

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Detalles Bibliográficos
Autores principales: Wang, Xin, Sun, Min, Chan, Chung Yu, Wu, Ling-Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9046444/
https://www.ncbi.nlm.nih.gov/pubmed/35497501
http://dx.doi.org/10.1016/j.crmeth.2022.100206
Descripción
Sumario:Vesicle exo- and endocytosis mediate important biological functions, including synaptic transmission. In this issue of Cell Reports Methods, Seong J. An et al. found that the fluorescently tagged C2 domain of phospholipase A(2) binds to membrane phosphatidylcholine and thus labels vesicle membrane, allowing for super-resolution and electron microscopic visualization of vesicle trafficking.

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