Peptide hydrogel with self-healing and redox-responsive properties

We have rationally designed a peptide that assembles into a redox-responsive, antimicrobial metallohydrogel. The resulting self-healing material can be rapidly reduced by ascorbate under physiological conditions and demonstrates a remarkable 160-fold change in hydrogel stiffness upon reduction. We p...

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Detalles Bibliográficos
Autores principales: D’Souza, Areetha, Marshall, Liam R., Yoon, Jennifer, Kulesha, Alona, Edirisinghe, Dona I. U., Chandrasekaran, Siddarth, Rathee, Parth, Prabhakar, Rajeev, Makhlynets, Olga V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Nature Singapore 2022
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9046503/
https://www.ncbi.nlm.nih.gov/pubmed/35478076
http://dx.doi.org/10.1186/s40580-022-00309-7
Descripción
Sumario:We have rationally designed a peptide that assembles into a redox-responsive, antimicrobial metallohydrogel. The resulting self-healing material can be rapidly reduced by ascorbate under physiological conditions and demonstrates a remarkable 160-fold change in hydrogel stiffness upon reduction. We provide a computational model of the hydrogel, explaining why position of nitrogen in non-natural amino acid pyridyl-alanine results in drastically different gelation properties of peptides with metal ions. Given its antimicrobial and rheological properties, the newly designed hydrogel can be used for removable wound dressing application, addressing a major unmet need in clinical care. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s40580-022-00309-7.

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