Peptide hydrogel with self-healing and redox-responsive properties

We have rationally designed a peptide that assembles into a redox-responsive, antimicrobial metallohydrogel. The resulting self-healing material can be rapidly reduced by ascorbate under physiological conditions and demonstrates a remarkable 160-fold change in hydrogel stiffness upon reduction. We p...

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Autores principales: D’Souza, Areetha, Marshall, Liam R., Yoon, Jennifer, Kulesha, Alona, Edirisinghe, Dona I. U., Chandrasekaran, Siddarth, Rathee, Parth, Prabhakar, Rajeev, Makhlynets, Olga V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Nature Singapore 2022
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9046503/
https://www.ncbi.nlm.nih.gov/pubmed/35478076
http://dx.doi.org/10.1186/s40580-022-00309-7
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author D’Souza, Areetha
Marshall, Liam R.
Yoon, Jennifer
Kulesha, Alona
Edirisinghe, Dona I. U.
Chandrasekaran, Siddarth
Rathee, Parth
Prabhakar, Rajeev
Makhlynets, Olga V.
author_facet D’Souza, Areetha
Marshall, Liam R.
Yoon, Jennifer
Kulesha, Alona
Edirisinghe, Dona I. U.
Chandrasekaran, Siddarth
Rathee, Parth
Prabhakar, Rajeev
Makhlynets, Olga V.
author_sort D’Souza, Areetha
collection PubMed
description We have rationally designed a peptide that assembles into a redox-responsive, antimicrobial metallohydrogel. The resulting self-healing material can be rapidly reduced by ascorbate under physiological conditions and demonstrates a remarkable 160-fold change in hydrogel stiffness upon reduction. We provide a computational model of the hydrogel, explaining why position of nitrogen in non-natural amino acid pyridyl-alanine results in drastically different gelation properties of peptides with metal ions. Given its antimicrobial and rheological properties, the newly designed hydrogel can be used for removable wound dressing application, addressing a major unmet need in clinical care. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s40580-022-00309-7.
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spelling pubmed-90465032022-05-07 Peptide hydrogel with self-healing and redox-responsive properties D’Souza, Areetha Marshall, Liam R. Yoon, Jennifer Kulesha, Alona Edirisinghe, Dona I. U. Chandrasekaran, Siddarth Rathee, Parth Prabhakar, Rajeev Makhlynets, Olga V. Nano Converg Communication We have rationally designed a peptide that assembles into a redox-responsive, antimicrobial metallohydrogel. The resulting self-healing material can be rapidly reduced by ascorbate under physiological conditions and demonstrates a remarkable 160-fold change in hydrogel stiffness upon reduction. We provide a computational model of the hydrogel, explaining why position of nitrogen in non-natural amino acid pyridyl-alanine results in drastically different gelation properties of peptides with metal ions. Given its antimicrobial and rheological properties, the newly designed hydrogel can be used for removable wound dressing application, addressing a major unmet need in clinical care. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s40580-022-00309-7. Springer Nature Singapore 2022-04-27 /pmc/articles/PMC9046503/ /pubmed/35478076 http://dx.doi.org/10.1186/s40580-022-00309-7 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Communication
D’Souza, Areetha
Marshall, Liam R.
Yoon, Jennifer
Kulesha, Alona
Edirisinghe, Dona I. U.
Chandrasekaran, Siddarth
Rathee, Parth
Prabhakar, Rajeev
Makhlynets, Olga V.
Peptide hydrogel with self-healing and redox-responsive properties
title Peptide hydrogel with self-healing and redox-responsive properties
title_full Peptide hydrogel with self-healing and redox-responsive properties
title_fullStr Peptide hydrogel with self-healing and redox-responsive properties
title_full_unstemmed Peptide hydrogel with self-healing and redox-responsive properties
title_short Peptide hydrogel with self-healing and redox-responsive properties
title_sort peptide hydrogel with self-healing and redox-responsive properties
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9046503/
https://www.ncbi.nlm.nih.gov/pubmed/35478076
http://dx.doi.org/10.1186/s40580-022-00309-7
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