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Non-Newtonian Endothelial Shear Stress Simulation: Does It Matter?

Patient-specific coronary endothelial shear stress (ESS) calculations using Newtonian and non-Newtonian rheological models were performed to assess whether the common assumption of Newtonian blood behavior offers similar results to a more realistic but computationally expensive non-Newtonian model....

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Autores principales: Thondapu, Vikas, Shishikura, Daisuke, Dijkstra, Jouke, Zhu, Shuang J., Revalor, Eve, Serruys, Patrick W., van Gaal, William J., Poon, Eric K. W., Ooi, Andrew, Barlis, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9046559/
https://www.ncbi.nlm.nih.gov/pubmed/35497989
http://dx.doi.org/10.3389/fcvm.2022.835270
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author Thondapu, Vikas
Shishikura, Daisuke
Dijkstra, Jouke
Zhu, Shuang J.
Revalor, Eve
Serruys, Patrick W.
van Gaal, William J.
Poon, Eric K. W.
Ooi, Andrew
Barlis, Peter
author_facet Thondapu, Vikas
Shishikura, Daisuke
Dijkstra, Jouke
Zhu, Shuang J.
Revalor, Eve
Serruys, Patrick W.
van Gaal, William J.
Poon, Eric K. W.
Ooi, Andrew
Barlis, Peter
author_sort Thondapu, Vikas
collection PubMed
description Patient-specific coronary endothelial shear stress (ESS) calculations using Newtonian and non-Newtonian rheological models were performed to assess whether the common assumption of Newtonian blood behavior offers similar results to a more realistic but computationally expensive non-Newtonian model. 16 coronary arteries (from 16 patients) were reconstructed from optical coherence tomographic (OCT) imaging. Pulsatile CFD simulations using Newtonian and the Quemada non-Newtonian model were performed. Endothelial shear stress (ESS) and other indices were compared. Exploratory indices including local blood viscosity (LBV) were calculated from non-Newtonian simulation data. Compared to the Newtonian results, the non-Newtonian model estimates significantly higher time-averaged ESS (1.69 (IQR 1.36)Pa versus 1.28 (1.16)Pa, p < 0.001) and ESS gradient (0.90 (1.20)Pa/mm versus 0.74 (1.03)Pa/mm, p < 0.001) throughout the cardiac cycle, under-estimating the low ESS (<1Pa) area (37.20 ± 13.57% versus 50.43 ± 14.16%, 95% CI 11.28–15.18, p < 0.001). Similar results were also found in the idealized artery simulations with non-Newtonian median ESS being higher than the Newtonian median ESS (healthy segments: 0.8238Pa versus 0.6618Pa, p < 0.001 proximal; 0.8179Pa versus 0.6610Pa, p < 0.001 distal; stenotic segments: 0.8196Pa versus 0.6611Pa, p < 0.001 proximal; 0.2546Pa versus 0.2245Pa, p < 0.001 distal) On average, the non-Newtonian model has a LBV of 1.45 times above the Newtonian model with an average peak LBV of 40-fold. Non-Newtonian blood model estimates higher quantitative ESS values than the Newtonian model. Incorporation of non-Newtonian blood behavior may improve the accuracy of ESS measurements. The non-Newtonian model also allows calculation of exploratory viscosity-based hemodynamic indices, such as local blood viscosity, which may offer additional information to detect underlying atherosclerosis.
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spelling pubmed-90465592022-04-29 Non-Newtonian Endothelial Shear Stress Simulation: Does It Matter? Thondapu, Vikas Shishikura, Daisuke Dijkstra, Jouke Zhu, Shuang J. Revalor, Eve Serruys, Patrick W. van Gaal, William J. Poon, Eric K. W. Ooi, Andrew Barlis, Peter Front Cardiovasc Med Cardiovascular Medicine Patient-specific coronary endothelial shear stress (ESS) calculations using Newtonian and non-Newtonian rheological models were performed to assess whether the common assumption of Newtonian blood behavior offers similar results to a more realistic but computationally expensive non-Newtonian model. 16 coronary arteries (from 16 patients) were reconstructed from optical coherence tomographic (OCT) imaging. Pulsatile CFD simulations using Newtonian and the Quemada non-Newtonian model were performed. Endothelial shear stress (ESS) and other indices were compared. Exploratory indices including local blood viscosity (LBV) were calculated from non-Newtonian simulation data. Compared to the Newtonian results, the non-Newtonian model estimates significantly higher time-averaged ESS (1.69 (IQR 1.36)Pa versus 1.28 (1.16)Pa, p < 0.001) and ESS gradient (0.90 (1.20)Pa/mm versus 0.74 (1.03)Pa/mm, p < 0.001) throughout the cardiac cycle, under-estimating the low ESS (<1Pa) area (37.20 ± 13.57% versus 50.43 ± 14.16%, 95% CI 11.28–15.18, p < 0.001). Similar results were also found in the idealized artery simulations with non-Newtonian median ESS being higher than the Newtonian median ESS (healthy segments: 0.8238Pa versus 0.6618Pa, p < 0.001 proximal; 0.8179Pa versus 0.6610Pa, p < 0.001 distal; stenotic segments: 0.8196Pa versus 0.6611Pa, p < 0.001 proximal; 0.2546Pa versus 0.2245Pa, p < 0.001 distal) On average, the non-Newtonian model has a LBV of 1.45 times above the Newtonian model with an average peak LBV of 40-fold. Non-Newtonian blood model estimates higher quantitative ESS values than the Newtonian model. Incorporation of non-Newtonian blood behavior may improve the accuracy of ESS measurements. The non-Newtonian model also allows calculation of exploratory viscosity-based hemodynamic indices, such as local blood viscosity, which may offer additional information to detect underlying atherosclerosis. Frontiers Media S.A. 2022-04-14 /pmc/articles/PMC9046559/ /pubmed/35497989 http://dx.doi.org/10.3389/fcvm.2022.835270 Text en Copyright © 2022 Thondapu, Shishikura, Dijkstra, Zhu, Revalor, Serruys, van Gaal, Poon, Ooi and Barlis. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cardiovascular Medicine
Thondapu, Vikas
Shishikura, Daisuke
Dijkstra, Jouke
Zhu, Shuang J.
Revalor, Eve
Serruys, Patrick W.
van Gaal, William J.
Poon, Eric K. W.
Ooi, Andrew
Barlis, Peter
Non-Newtonian Endothelial Shear Stress Simulation: Does It Matter?
title Non-Newtonian Endothelial Shear Stress Simulation: Does It Matter?
title_full Non-Newtonian Endothelial Shear Stress Simulation: Does It Matter?
title_fullStr Non-Newtonian Endothelial Shear Stress Simulation: Does It Matter?
title_full_unstemmed Non-Newtonian Endothelial Shear Stress Simulation: Does It Matter?
title_short Non-Newtonian Endothelial Shear Stress Simulation: Does It Matter?
title_sort non-newtonian endothelial shear stress simulation: does it matter?
topic Cardiovascular Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9046559/
https://www.ncbi.nlm.nih.gov/pubmed/35497989
http://dx.doi.org/10.3389/fcvm.2022.835270
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