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Immune Gene Signatures and Immunotypes in Immune Microenvironment Are Associated With Glioma Prognose

Glioma is the most common primary malignant brain tumor in adults with very poor prognosis. The limited new therapeutic strategies for glioma patients can be partially attributed to the complex tumor microenvironment. However, knowledge about the glioma immune microenvironment and the associated reg...

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Autores principales: Wang, Xiang-Xu, Cao, Haiyan, Zhai, Yulong, Deng, Shi-Zhou, Chao, Min, Hu, Yaqin, Mou, Yueyang, Guo, Shaochun, Zhao, Wenjian, Li, Chen, Jiao, Yang, Xue, Guolian, Han, Liying, Zhang, Hong-Mei, Wang, Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9046586/
https://www.ncbi.nlm.nih.gov/pubmed/35493457
http://dx.doi.org/10.3389/fimmu.2022.823910
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author Wang, Xiang-Xu
Cao, Haiyan
Zhai, Yulong
Deng, Shi-Zhou
Chao, Min
Hu, Yaqin
Mou, Yueyang
Guo, Shaochun
Zhao, Wenjian
Li, Chen
Jiao, Yang
Xue, Guolian
Han, Liying
Zhang, Hong-Mei
Wang, Liang
author_facet Wang, Xiang-Xu
Cao, Haiyan
Zhai, Yulong
Deng, Shi-Zhou
Chao, Min
Hu, Yaqin
Mou, Yueyang
Guo, Shaochun
Zhao, Wenjian
Li, Chen
Jiao, Yang
Xue, Guolian
Han, Liying
Zhang, Hong-Mei
Wang, Liang
author_sort Wang, Xiang-Xu
collection PubMed
description Glioma is the most common primary malignant brain tumor in adults with very poor prognosis. The limited new therapeutic strategies for glioma patients can be partially attributed to the complex tumor microenvironment. However, knowledge about the glioma immune microenvironment and the associated regulatory mechanisms is still lacking. In this study, we found that, different immune subtypes have a significant impact on patient survival. Glioma patients with a high immune response subtype had a shorter survival compared with patients with a low immune response subtype. Moreover, the number of B cell, T cell, NK cell, and in particular, the macrophage in the immune microenvironment of patients with a high immune response subtype were significantly enhanced. In addition, 132 genes were found to be related to glioma immunity. The functional analysis and verification of seven core genes showed that their expression levels were significantly correlated with the prognosis of glioma patients, and the results were consistent at tissue levels. These findings indicated that the glioma immune microenvironment was significantly correlated with the prognosis of glioma patients and multiple genes were involved in regulating the progression of glioma. The identified genes could be used to stratify glioma patients based on immune subgroup analysis, which may guide their clinical treatment regimen.
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spelling pubmed-90465862022-04-29 Immune Gene Signatures and Immunotypes in Immune Microenvironment Are Associated With Glioma Prognose Wang, Xiang-Xu Cao, Haiyan Zhai, Yulong Deng, Shi-Zhou Chao, Min Hu, Yaqin Mou, Yueyang Guo, Shaochun Zhao, Wenjian Li, Chen Jiao, Yang Xue, Guolian Han, Liying Zhang, Hong-Mei Wang, Liang Front Immunol Immunology Glioma is the most common primary malignant brain tumor in adults with very poor prognosis. The limited new therapeutic strategies for glioma patients can be partially attributed to the complex tumor microenvironment. However, knowledge about the glioma immune microenvironment and the associated regulatory mechanisms is still lacking. In this study, we found that, different immune subtypes have a significant impact on patient survival. Glioma patients with a high immune response subtype had a shorter survival compared with patients with a low immune response subtype. Moreover, the number of B cell, T cell, NK cell, and in particular, the macrophage in the immune microenvironment of patients with a high immune response subtype were significantly enhanced. In addition, 132 genes were found to be related to glioma immunity. The functional analysis and verification of seven core genes showed that their expression levels were significantly correlated with the prognosis of glioma patients, and the results were consistent at tissue levels. These findings indicated that the glioma immune microenvironment was significantly correlated with the prognosis of glioma patients and multiple genes were involved in regulating the progression of glioma. The identified genes could be used to stratify glioma patients based on immune subgroup analysis, which may guide their clinical treatment regimen. Frontiers Media S.A. 2022-04-14 /pmc/articles/PMC9046586/ /pubmed/35493457 http://dx.doi.org/10.3389/fimmu.2022.823910 Text en Copyright © 2022 Wang, Cao, Zhai, Deng, Chao, Hu, Mou, Guo, Zhao, Li, Jiao, Xue, Han, Zhang and Wang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Wang, Xiang-Xu
Cao, Haiyan
Zhai, Yulong
Deng, Shi-Zhou
Chao, Min
Hu, Yaqin
Mou, Yueyang
Guo, Shaochun
Zhao, Wenjian
Li, Chen
Jiao, Yang
Xue, Guolian
Han, Liying
Zhang, Hong-Mei
Wang, Liang
Immune Gene Signatures and Immunotypes in Immune Microenvironment Are Associated With Glioma Prognose
title Immune Gene Signatures and Immunotypes in Immune Microenvironment Are Associated With Glioma Prognose
title_full Immune Gene Signatures and Immunotypes in Immune Microenvironment Are Associated With Glioma Prognose
title_fullStr Immune Gene Signatures and Immunotypes in Immune Microenvironment Are Associated With Glioma Prognose
title_full_unstemmed Immune Gene Signatures and Immunotypes in Immune Microenvironment Are Associated With Glioma Prognose
title_short Immune Gene Signatures and Immunotypes in Immune Microenvironment Are Associated With Glioma Prognose
title_sort immune gene signatures and immunotypes in immune microenvironment are associated with glioma prognose
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9046586/
https://www.ncbi.nlm.nih.gov/pubmed/35493457
http://dx.doi.org/10.3389/fimmu.2022.823910
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