Cargando…

Cumulative Evidence for Associations Between Genetic Variants in Interleukin 6 Receptor Gene and Human Diseases and Phenotypes

BACKGROUND: Genetic studies have linked polymorphisms in the interleukin 6 receptor (IL6R) gene to the risk of multiple human diseases and phenotypes, yet have reported inconsistent results. We aimed to synthesize current knowledge of variants in the IL6R gene on the risk of diseases and phenotypes....

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Min, Bai, Ye, Wang, Yutong, Cui, Huijie, Tang, Mingshuang, Wang, Lanbing, Wang, Xin, Gu, Dongqing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9046675/ https://www.ncbi.nlm.nih.gov/pubmed/35493452 http://dx.doi.org/10.3389/fimmu.2022.860703

Ejemplares similares

Cumulative evidence for associations between genetic variants in interleukin 17 family gene and risk of human diseases
por: Liu, Tianyu, et al.
Publicado: (2022)

The Causal Relationships Between Extrinsic Exposures and Risk of Prostate Cancer: A Phenome-Wide Mendelian Randomization Study
por: Gu, Dongqing, et al.
Publicado: (2022)

Addictive behavior and incident gallstone disease: A dose–response meta-analysis and Mendelian randomization study
por: Bai, Ye, et al.
Publicado: (2022)

The impact of immunoglobulin G N-glycosylation level on COVID-19 outcome: evidence from a Mendelian randomization study
por: Long, Feiwu, et al.
Publicado: (2023)

Sex Disparities in the Clinical Characteristics, Synchronous Distant Metastasis Occurrence and Prognosis: A Pan-cancer Analysis
por: Wang, Yutong, et al.
Publicado: (2021)

Interleukin-33 Promotes Cell Survival via p38 MAPK-Mediated Interleukin-6 Gene Expression and Release in Pediatric AML
por: Wang, Yiqian, et al.
Publicado: (2020)

Epigenetic Regulation of Interleukin 6 by Histone Acetylation in Macrophages and Its Role in Paraquat-Induced Pulmonary Fibrosis
por: Hu, Lingli, et al.
Publicado: (2017)

Interleukin-6 and pulmonary hypertension: from physiopathology to therapy
por: Xu, Wei-Jie, et al.
Publicado: (2023)

Revisiting the 1986 Molecular Cloning of Interleukin 6
por: Hirano, Toshio
Publicado: (2014)

Interleukin-6 inhibition in the treatment of autoinflammatory diseases
por: Koga, Tomohiro, et al.
Publicado: (2022)

Interleukin 6: at the interface of human health and disease
por: Grebenciucova, Elena, et al.
Publicado: (2023)

Genetic Variants Associated with Thyroid Cancer Risk: Comprehensive Research Synopsis, Meta-Analysis, and Cumulative Epidemiological Evidence
por: Ran, Ran, et al.
Publicado: (2021)

Structural Understanding of Interleukin 6 Family Cytokine Signaling and Targeted Therapies: Focus on Interleukin 11
por: Metcalfe, Riley D., et al.
Publicado: (2020)

Association Between Systemic Lupus Erythematosus and Cancer Morbidity and Mortality: Findings From Cohort Studies
por: Zhang, Min, et al.
Publicado: (2022)

Interleukin 6-regulated macrophage polarization controls atherosclerosis-associated vascular intimal hyperplasia
por: Chen, Jiaquan, et al.
Publicado: (2022)

Interleukin-18 and IL-18BP in inflammatory dermatological diseases
por: Wang, Xiaoyun, et al.
Publicado: (2023)

The Role of Interleukin-6 (IL-6) in the Systemic Inflammatory Response in Xenograft Recipients and in Pig Kidney Xenograft Failure
por: Zhang, Guoqiang, et al.
Publicado: (2021)

Structural Mimicry of Receptor Interaction by Antagonistic Interleukin-6 (IL-6) Antibodies
por: Blanchetot, Christophe, et al.
Publicado: (2016)

Neonatal T Helper 17 Responses Are Skewed Towards an Immunoregulatory Interleukin-22 Phenotype
por: Razzaghian, Hamid R., et al.
Publicado: (2021)

Inflammatory bowel diseases, interleukin-6 and interleukin-6 receptor subunit alpha in causal association with cerebral cortical structure: a Mendelian randomization analysis
por: Liu, Chunlong, et al.
Publicado: (2023)

Effects of Neutrophil-to-Lymphocyte Ratio Combined With Interleukin-6 in Predicting 28-Day Mortality in Patients With Sepsis
por: Liu, Shuangqing, et al.
Publicado: (2021)

Epstein Barr Virus Interleukin 10 Suppresses Anti-inflammatory Phenotype in Human Monocytes
por: Jog, Neelakshi R., et al.
Publicado: (2018)

Investigation of Genetic Determinants of Glioma Immune Phenotype by Integrative Immunogenomic Scale Analysis
por: Zhao, Binghao, et al.
Publicado: (2021)

Analysis of Interleukin-1 Signaling Alterations of Colon Adenocarcinoma Identified Implications for Immunotherapy
por: Zhou, Xiaogang, et al.
Publicado: (2021)

Targeting the Interleukin-23/Interleukin-17 Inflammatory Pathway: Successes and Failures in the Treatment of Axial Spondyloarthritis
por: Wang, Runsheng, et al.
Publicado: (2021)

Interleukin-6 Signaling Pathway and Its Role in Kidney Disease: An Update
por: Su, Hua, et al.
Publicado: (2017)

Genetic Association of Interleukin 33/ST2 Polymorphisms With Behcet’s Uveitis
por: Pei, Minghang, et al.
Publicado: (2021)

Donor genetic variants in interleukin-6 and interleukin-6 receptor associate with biopsy-proven rejection following kidney transplantation
por: Poppelaars, Felix, et al.
Publicado: (2021)

Cumulative evidence for association of rhinitis and depression
por: Wang, Jing, et al.
Publicado: (2021)

Cumulative Roles for Epstein-Barr Virus, Human Endogenous Retroviruses, and Human Herpes Virus-6 in Driving an Inflammatory Cascade Underlying MS Pathogenesis
por: Meier, Ute-Christiane, et al.
Publicado: (2021)

Weak association between the interleukin-8 rs4073 polymorphism and acute pancreatitis: a cumulative meta-analysis
por: Li, Yening, et al.
Publicado: (2019)

Optimisation of anti-interleukin-6 therapy: Precision medicine through mathematical modelling
por: Rossi, Jean-François, et al.
Publicado: (2022)

A Novel Humanized Anti-Interleukin-6 Antibody HZ0408b With Anti-Rheumatoid Arthritis Therapeutic Potential
por: Liu, Xiaolei, et al.
Publicado: (2022)

Kappa Free Light Chains, Soluble Interleukin-2 Receptor, and Interleukin-6 Help Explore Patients Presenting With Brain White Matter Hyperintensities
por: Levraut, Michael, et al.
Publicado: (2022)

Salivary interleukin 6, interleukin 8, interleukin 17A, and tumour necrosis factor α levels in patients with periodontitis and rheumatoid arthritis
por: Kaczyński, Tomasz, et al.
Publicado: (2019)

Transcriptome Analysis of Immune Receptor Activation and Energy Metabolism Reduction as the Underlying Mechanisms in Interleukin-6-Induced Skeletal Muscle Atrophy
por: Sun, Hualin, et al.
Publicado: (2021)

Cumulative evidence for relationships between multiple variants in 8q24 and colorectal cancer incidence
por: Tong, Yu, et al.
Publicado: (2018)

Novel genetic variants in differentiated thyroid cancer and assessment of the cumulative risk
por: Figlioli, Gisella, et al.
Publicado: (2015)

Cumulative effects of common genetic variants on risk of sudden cardiac death
por: Huertas-Vazquez, Adriana, et al.
Publicado: (2015)

Interleukin-33 Contributes to the Induction of Th9 Cells and Antitumor Efficacy by Dectin-1-Activated Dendritic Cells
por: Chen, Jintong, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_avrtdt9cantjtbsjk70pac79mh