Cargando…

A Hydrogen Bonds-Crosslinked Hydrogels With Self-Healing and Adhesive Properties for Hemostatic

Hydrogels with adhesive properties have the potential for rapid haemostasis and wound healing in uncontrolled non-pressurized surface bleeding. Herein, a typical hydrogen bond-crosslinked hydrogel with the above functions was constructed by directly mixing solutions of humic acid (HA) and polyvinylp...

Descripción completa

Detalles Bibliográficos
Autores principales: Yu, Han, Xiao, Qiaohong, Qi, Guilin, Chen, Feixiang, Tu, Biyue, Zhang, Suo, Li, Yinping, Chen, Yun, Yu, Hui, Duan, Peng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9046721/
https://www.ncbi.nlm.nih.gov/pubmed/35497342
http://dx.doi.org/10.3389/fbioe.2022.855013
_version_ 1784695572022689792
author Yu, Han
Xiao, Qiaohong
Qi, Guilin
Chen, Feixiang
Tu, Biyue
Zhang, Suo
Li, Yinping
Chen, Yun
Yu, Hui
Duan, Peng
author_facet Yu, Han
Xiao, Qiaohong
Qi, Guilin
Chen, Feixiang
Tu, Biyue
Zhang, Suo
Li, Yinping
Chen, Yun
Yu, Hui
Duan, Peng
author_sort Yu, Han
collection PubMed
description Hydrogels with adhesive properties have the potential for rapid haemostasis and wound healing in uncontrolled non-pressurized surface bleeding. Herein, a typical hydrogen bond-crosslinked hydrogel with the above functions was constructed by directly mixing solutions of humic acid (HA) and polyvinylpyrrolidone (PVP), in which the HA worked as a crosslinking agent to form hydrogen bonds with the PVP. By altering the concentration of HA, a cluster of stable and uniform hydrogels were prepared within 10 s. The dynamic and reversible nature of the hydrogen bonds gave the HA/PVP complex (HPC) hydrogels injectability and good flexibility, as well as a self-healing ability. Moreover, the numerous functional groups in the hydrogels enhanced the cohesion strength and interaction on the interface between the hydrogel and the substrate, endowing them with good adhesion properties. The unique chemical composition and cross-linking mechanism gave the HPC hydrogel good biocompatibility. Taking advantage of all these features, the HPC hydrogels obtained in this work were broadly applied as haemostatic agents and showed a good therapeutic effect. This work might lead to an improvement in the development of multifunctional non-covalent hydrogels for application to biomaterials.
format Online
Article
Text
id pubmed-9046721
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-90467212022-04-29 A Hydrogen Bonds-Crosslinked Hydrogels With Self-Healing and Adhesive Properties for Hemostatic Yu, Han Xiao, Qiaohong Qi, Guilin Chen, Feixiang Tu, Biyue Zhang, Suo Li, Yinping Chen, Yun Yu, Hui Duan, Peng Front Bioeng Biotechnol Bioengineering and Biotechnology Hydrogels with adhesive properties have the potential for rapid haemostasis and wound healing in uncontrolled non-pressurized surface bleeding. Herein, a typical hydrogen bond-crosslinked hydrogel with the above functions was constructed by directly mixing solutions of humic acid (HA) and polyvinylpyrrolidone (PVP), in which the HA worked as a crosslinking agent to form hydrogen bonds with the PVP. By altering the concentration of HA, a cluster of stable and uniform hydrogels were prepared within 10 s. The dynamic and reversible nature of the hydrogen bonds gave the HA/PVP complex (HPC) hydrogels injectability and good flexibility, as well as a self-healing ability. Moreover, the numerous functional groups in the hydrogels enhanced the cohesion strength and interaction on the interface between the hydrogel and the substrate, endowing them with good adhesion properties. The unique chemical composition and cross-linking mechanism gave the HPC hydrogel good biocompatibility. Taking advantage of all these features, the HPC hydrogels obtained in this work were broadly applied as haemostatic agents and showed a good therapeutic effect. This work might lead to an improvement in the development of multifunctional non-covalent hydrogels for application to biomaterials. Frontiers Media S.A. 2022-04-14 /pmc/articles/PMC9046721/ /pubmed/35497342 http://dx.doi.org/10.3389/fbioe.2022.855013 Text en Copyright © 2022 Yu, Xiao, Qi, Chen, Tu, Zhang, Li, Chen, Yu and Duan. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Bioengineering and Biotechnology
Yu, Han
Xiao, Qiaohong
Qi, Guilin
Chen, Feixiang
Tu, Biyue
Zhang, Suo
Li, Yinping
Chen, Yun
Yu, Hui
Duan, Peng
A Hydrogen Bonds-Crosslinked Hydrogels With Self-Healing and Adhesive Properties for Hemostatic
title A Hydrogen Bonds-Crosslinked Hydrogels With Self-Healing and Adhesive Properties for Hemostatic
title_full A Hydrogen Bonds-Crosslinked Hydrogels With Self-Healing and Adhesive Properties for Hemostatic
title_fullStr A Hydrogen Bonds-Crosslinked Hydrogels With Self-Healing and Adhesive Properties for Hemostatic
title_full_unstemmed A Hydrogen Bonds-Crosslinked Hydrogels With Self-Healing and Adhesive Properties for Hemostatic
title_short A Hydrogen Bonds-Crosslinked Hydrogels With Self-Healing and Adhesive Properties for Hemostatic
title_sort hydrogen bonds-crosslinked hydrogels with self-healing and adhesive properties for hemostatic
topic Bioengineering and Biotechnology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9046721/
https://www.ncbi.nlm.nih.gov/pubmed/35497342
http://dx.doi.org/10.3389/fbioe.2022.855013
work_keys_str_mv AT yuhan ahydrogenbondscrosslinkedhydrogelswithselfhealingandadhesivepropertiesforhemostatic
AT xiaoqiaohong ahydrogenbondscrosslinkedhydrogelswithselfhealingandadhesivepropertiesforhemostatic
AT qiguilin ahydrogenbondscrosslinkedhydrogelswithselfhealingandadhesivepropertiesforhemostatic
AT chenfeixiang ahydrogenbondscrosslinkedhydrogelswithselfhealingandadhesivepropertiesforhemostatic
AT tubiyue ahydrogenbondscrosslinkedhydrogelswithselfhealingandadhesivepropertiesforhemostatic
AT zhangsuo ahydrogenbondscrosslinkedhydrogelswithselfhealingandadhesivepropertiesforhemostatic
AT liyinping ahydrogenbondscrosslinkedhydrogelswithselfhealingandadhesivepropertiesforhemostatic
AT chenyun ahydrogenbondscrosslinkedhydrogelswithselfhealingandadhesivepropertiesforhemostatic
AT yuhui ahydrogenbondscrosslinkedhydrogelswithselfhealingandadhesivepropertiesforhemostatic
AT duanpeng ahydrogenbondscrosslinkedhydrogelswithselfhealingandadhesivepropertiesforhemostatic
AT yuhan hydrogenbondscrosslinkedhydrogelswithselfhealingandadhesivepropertiesforhemostatic
AT xiaoqiaohong hydrogenbondscrosslinkedhydrogelswithselfhealingandadhesivepropertiesforhemostatic
AT qiguilin hydrogenbondscrosslinkedhydrogelswithselfhealingandadhesivepropertiesforhemostatic
AT chenfeixiang hydrogenbondscrosslinkedhydrogelswithselfhealingandadhesivepropertiesforhemostatic
AT tubiyue hydrogenbondscrosslinkedhydrogelswithselfhealingandadhesivepropertiesforhemostatic
AT zhangsuo hydrogenbondscrosslinkedhydrogelswithselfhealingandadhesivepropertiesforhemostatic
AT liyinping hydrogenbondscrosslinkedhydrogelswithselfhealingandadhesivepropertiesforhemostatic
AT chenyun hydrogenbondscrosslinkedhydrogelswithselfhealingandadhesivepropertiesforhemostatic
AT yuhui hydrogenbondscrosslinkedhydrogelswithselfhealingandadhesivepropertiesforhemostatic
AT duanpeng hydrogenbondscrosslinkedhydrogelswithselfhealingandadhesivepropertiesforhemostatic