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Cannabis Use and Neuroadaptation: A Call for Δ(9)-Tetrahydrocannabinol Challenge Studies

Currently, the assessment of the neurobehavioral consequences of repeated cannabis use is restricted to studies in which brain function of chronic cannabis users is compared to that of non-cannabis using controls. The assumption of such studies is that changes in brain function of chronic users are...

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Autores principales: Ramaekers, Johannes G., Theunissen, Eef L., van Ruitenbeek, Peter, Mason, Natasha L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9046729/
https://www.ncbi.nlm.nih.gov/pubmed/35492732
http://dx.doi.org/10.3389/fpsyt.2022.870750
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author Ramaekers, Johannes G.
Theunissen, Eef L.
van Ruitenbeek, Peter
Mason, Natasha L.
author_facet Ramaekers, Johannes G.
Theunissen, Eef L.
van Ruitenbeek, Peter
Mason, Natasha L.
author_sort Ramaekers, Johannes G.
collection PubMed
description Currently, the assessment of the neurobehavioral consequences of repeated cannabis use is restricted to studies in which brain function of chronic cannabis users is compared to that of non-cannabis using controls. The assumption of such studies is that changes in brain function of chronic users are caused by repeated and prolonged exposure to acute cannabis intoxication. However, differences in brain function between chronic cannabis users and non-users might also arise from confounding factors such as polydrug use, alcohol use, withdrawal, economic status, or lifestyle conditions. We propose a methodology that highlights the relevance of acute Δ(9)-tetrahydrocannabinol (THC) dosing studies for a direct assessment of neuroadaptations in chronic cannabis users. The approach includes quantification of neurochemical, receptor, and functional brain network changes in response to an acute cannabis challenge, as well as stratification of cannabis using groups ranging from occasional to cannabis-dependent individuals. The methodology allows for an evaluation of THC induced neuroadaptive and neurocognitive changes across cannabis use history, that can inform neurobiological models on reward driven, compulsive cannabis use.
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spelling pubmed-90467292022-04-29 Cannabis Use and Neuroadaptation: A Call for Δ(9)-Tetrahydrocannabinol Challenge Studies Ramaekers, Johannes G. Theunissen, Eef L. van Ruitenbeek, Peter Mason, Natasha L. Front Psychiatry Psychiatry Currently, the assessment of the neurobehavioral consequences of repeated cannabis use is restricted to studies in which brain function of chronic cannabis users is compared to that of non-cannabis using controls. The assumption of such studies is that changes in brain function of chronic users are caused by repeated and prolonged exposure to acute cannabis intoxication. However, differences in brain function between chronic cannabis users and non-users might also arise from confounding factors such as polydrug use, alcohol use, withdrawal, economic status, or lifestyle conditions. We propose a methodology that highlights the relevance of acute Δ(9)-tetrahydrocannabinol (THC) dosing studies for a direct assessment of neuroadaptations in chronic cannabis users. The approach includes quantification of neurochemical, receptor, and functional brain network changes in response to an acute cannabis challenge, as well as stratification of cannabis using groups ranging from occasional to cannabis-dependent individuals. The methodology allows for an evaluation of THC induced neuroadaptive and neurocognitive changes across cannabis use history, that can inform neurobiological models on reward driven, compulsive cannabis use. Frontiers Media S.A. 2022-04-14 /pmc/articles/PMC9046729/ /pubmed/35492732 http://dx.doi.org/10.3389/fpsyt.2022.870750 Text en Copyright © 2022 Ramaekers, Theunissen, van Ruitenbeek and Mason. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychiatry
Ramaekers, Johannes G.
Theunissen, Eef L.
van Ruitenbeek, Peter
Mason, Natasha L.
Cannabis Use and Neuroadaptation: A Call for Δ(9)-Tetrahydrocannabinol Challenge Studies
title Cannabis Use and Neuroadaptation: A Call for Δ(9)-Tetrahydrocannabinol Challenge Studies
title_full Cannabis Use and Neuroadaptation: A Call for Δ(9)-Tetrahydrocannabinol Challenge Studies
title_fullStr Cannabis Use and Neuroadaptation: A Call for Δ(9)-Tetrahydrocannabinol Challenge Studies
title_full_unstemmed Cannabis Use and Neuroadaptation: A Call for Δ(9)-Tetrahydrocannabinol Challenge Studies
title_short Cannabis Use and Neuroadaptation: A Call for Δ(9)-Tetrahydrocannabinol Challenge Studies
title_sort cannabis use and neuroadaptation: a call for δ(9)-tetrahydrocannabinol challenge studies
topic Psychiatry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9046729/
https://www.ncbi.nlm.nih.gov/pubmed/35492732
http://dx.doi.org/10.3389/fpsyt.2022.870750
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