Application of hiPSC as a Drug Tester Via Mimicking a Personalized Mini Heart

Human induced pluripotent stem cells (hIPSC) have been used to produce almost all types of human cells currently, which makes them into several potential applications with replicated patient-specific genotype. Furthermore, hIPSC derived cardiomyocytes assembled engineering heart tissue can be establ...

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Detalles Bibliográficos
Autores principales: Wei, Li, Xia, Shutao, Li, Yifei, Qi, Yan, Wang, Yue, Zhang, Donghui, Hua, Yimin, Luo, Shuhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9046785/
https://www.ncbi.nlm.nih.gov/pubmed/35495144
http://dx.doi.org/10.3389/fgene.2022.891159
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author Wei, Li
Xia, Shutao
Li, Yifei
Qi, Yan
Wang, Yue
Zhang, Donghui
Hua, Yimin
Luo, Shuhua
author_facet Wei, Li
Xia, Shutao
Li, Yifei
Qi, Yan
Wang, Yue
Zhang, Donghui
Hua, Yimin
Luo, Shuhua
author_sort Wei, Li
collection PubMed
description Human induced pluripotent stem cells (hIPSC) have been used to produce almost all types of human cells currently, which makes them into several potential applications with replicated patient-specific genotype. Furthermore, hIPSC derived cardiomyocytes assembled engineering heart tissue can be established to achieve multiple functional evaluations by tissue engineering technology. This short review summarized the current advanced applications based on the hIPSC derived heart tissue in molecular mechanisms elucidating and high throughput drug screening.
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spelling pubmed-90467852022-04-29 Application of hiPSC as a Drug Tester Via Mimicking a Personalized Mini Heart Wei, Li Xia, Shutao Li, Yifei Qi, Yan Wang, Yue Zhang, Donghui Hua, Yimin Luo, Shuhua Front Genet Genetics Human induced pluripotent stem cells (hIPSC) have been used to produce almost all types of human cells currently, which makes them into several potential applications with replicated patient-specific genotype. Furthermore, hIPSC derived cardiomyocytes assembled engineering heart tissue can be established to achieve multiple functional evaluations by tissue engineering technology. This short review summarized the current advanced applications based on the hIPSC derived heart tissue in molecular mechanisms elucidating and high throughput drug screening. Frontiers Media S.A. 2022-04-14 /pmc/articles/PMC9046785/ /pubmed/35495144 http://dx.doi.org/10.3389/fgene.2022.891159 Text en Copyright © 2022 Wei, Xia, Li, Qi, Wang, Zhang, Hua and Luo. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Genetics
Wei, Li
Xia, Shutao
Li, Yifei
Qi, Yan
Wang, Yue
Zhang, Donghui
Hua, Yimin
Luo, Shuhua
Application of hiPSC as a Drug Tester Via Mimicking a Personalized Mini Heart
title Application of hiPSC as a Drug Tester Via Mimicking a Personalized Mini Heart
title_full Application of hiPSC as a Drug Tester Via Mimicking a Personalized Mini Heart
title_fullStr Application of hiPSC as a Drug Tester Via Mimicking a Personalized Mini Heart
title_full_unstemmed Application of hiPSC as a Drug Tester Via Mimicking a Personalized Mini Heart
title_short Application of hiPSC as a Drug Tester Via Mimicking a Personalized Mini Heart
title_sort application of hipsc as a drug tester via mimicking a personalized mini heart
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9046785/
https://www.ncbi.nlm.nih.gov/pubmed/35495144
http://dx.doi.org/10.3389/fgene.2022.891159
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