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Inflammation subtypes in psychosis and their relationships with genetic risk for psychiatric and cardiometabolic disorders

Cardiometabolic disorders have known inflammatory implications, and peripheral measures of inflammation and cardiometabolic disorders are common in persons with psychotic disorders. Inflammatory signatures are also related to neurobiological and behavioral changes in psychosis. Relationships between...

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Autores principales: Zhang, Lusi, Lizano, Paulo, Guo, Bin, Xu, Yanxun, Rubin, Leah H., Hill, S. Kristian, Alliey-Rodriguez, Ney, Lee, Adam M., Wu, Baolin, Keedy, Sarah K., Tamminga, Carol A., Pearlson, Godfrey D., Clementz, Brett A., Keshavan, Matcheri S., Gershon, Elliot S., Sweeney, John A., Bishop, Jeffrey R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9046804/
https://www.ncbi.nlm.nih.gov/pubmed/35496776
http://dx.doi.org/10.1016/j.bbih.2022.100459
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author Zhang, Lusi
Lizano, Paulo
Guo, Bin
Xu, Yanxun
Rubin, Leah H.
Hill, S. Kristian
Alliey-Rodriguez, Ney
Lee, Adam M.
Wu, Baolin
Keedy, Sarah K.
Tamminga, Carol A.
Pearlson, Godfrey D.
Clementz, Brett A.
Keshavan, Matcheri S.
Gershon, Elliot S.
Sweeney, John A.
Bishop, Jeffrey R.
author_facet Zhang, Lusi
Lizano, Paulo
Guo, Bin
Xu, Yanxun
Rubin, Leah H.
Hill, S. Kristian
Alliey-Rodriguez, Ney
Lee, Adam M.
Wu, Baolin
Keedy, Sarah K.
Tamminga, Carol A.
Pearlson, Godfrey D.
Clementz, Brett A.
Keshavan, Matcheri S.
Gershon, Elliot S.
Sweeney, John A.
Bishop, Jeffrey R.
author_sort Zhang, Lusi
collection PubMed
description Cardiometabolic disorders have known inflammatory implications, and peripheral measures of inflammation and cardiometabolic disorders are common in persons with psychotic disorders. Inflammatory signatures are also related to neurobiological and behavioral changes in psychosis. Relationships between systemic inflammation and cardiometabolic genetic risk in persons with psychosis have not been examined. Thirteen peripheral inflammatory markers and genome-wide genotyping were assessed in 122 participants (n ​= ​86 psychosis, n ​= ​36 healthy controls) of European ancestry. Cluster analyses of inflammatory markers classified higher and lower inflammation subgroups. Single-trait genetic risk scores (GRS) were constructed for each participant using previously reported GWAS summary statistics for the following traits: schizophrenia, bipolar disorder, major depressive disorder, coronary artery disease, type-2 diabetes, low-density lipoprotein, high-density lipoprotein, triglycerides, and waist-to-hip ratio. Genetic correlations across traits were quantified. Principal component (PC) analysis of the cardiometabolic GRSs generated six PC loadings used in regression models to examine associations with inflammation markers. Functional module discovery explored biological mechanisms of the inflammation association of cardiometabolic GRS genes. A subgroup of 38% persons with psychotic disorders was characterized with higher inflammation status. These higher inflammation individuals had lower BACS scores (p ​= ​0.038) compared to those with lower inflammation. The first PC of the cardiometabolic GRS matrix was related to higher inflammation status in persons with psychotic disorders (OR ​= ​2.037, p ​= ​0.001). Two of eight modules within the functional interaction network of cardiometabolic GRS genes were enriched for immune processes. Cardiometabolic genetic risk may predispose some individuals with psychosis to elevated inflammation which adversely impacts cognition associated with illness.
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spelling pubmed-90468042022-04-29 Inflammation subtypes in psychosis and their relationships with genetic risk for psychiatric and cardiometabolic disorders Zhang, Lusi Lizano, Paulo Guo, Bin Xu, Yanxun Rubin, Leah H. Hill, S. Kristian Alliey-Rodriguez, Ney Lee, Adam M. Wu, Baolin Keedy, Sarah K. Tamminga, Carol A. Pearlson, Godfrey D. Clementz, Brett A. Keshavan, Matcheri S. Gershon, Elliot S. Sweeney, John A. Bishop, Jeffrey R. Brain Behav Immun Health Full Length Article Cardiometabolic disorders have known inflammatory implications, and peripheral measures of inflammation and cardiometabolic disorders are common in persons with psychotic disorders. Inflammatory signatures are also related to neurobiological and behavioral changes in psychosis. Relationships between systemic inflammation and cardiometabolic genetic risk in persons with psychosis have not been examined. Thirteen peripheral inflammatory markers and genome-wide genotyping were assessed in 122 participants (n ​= ​86 psychosis, n ​= ​36 healthy controls) of European ancestry. Cluster analyses of inflammatory markers classified higher and lower inflammation subgroups. Single-trait genetic risk scores (GRS) were constructed for each participant using previously reported GWAS summary statistics for the following traits: schizophrenia, bipolar disorder, major depressive disorder, coronary artery disease, type-2 diabetes, low-density lipoprotein, high-density lipoprotein, triglycerides, and waist-to-hip ratio. Genetic correlations across traits were quantified. Principal component (PC) analysis of the cardiometabolic GRSs generated six PC loadings used in regression models to examine associations with inflammation markers. Functional module discovery explored biological mechanisms of the inflammation association of cardiometabolic GRS genes. A subgroup of 38% persons with psychotic disorders was characterized with higher inflammation status. These higher inflammation individuals had lower BACS scores (p ​= ​0.038) compared to those with lower inflammation. The first PC of the cardiometabolic GRS matrix was related to higher inflammation status in persons with psychotic disorders (OR ​= ​2.037, p ​= ​0.001). Two of eight modules within the functional interaction network of cardiometabolic GRS genes were enriched for immune processes. Cardiometabolic genetic risk may predispose some individuals with psychosis to elevated inflammation which adversely impacts cognition associated with illness. Elsevier 2022-04-08 /pmc/articles/PMC9046804/ /pubmed/35496776 http://dx.doi.org/10.1016/j.bbih.2022.100459 Text en © 2022 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Full Length Article
Zhang, Lusi
Lizano, Paulo
Guo, Bin
Xu, Yanxun
Rubin, Leah H.
Hill, S. Kristian
Alliey-Rodriguez, Ney
Lee, Adam M.
Wu, Baolin
Keedy, Sarah K.
Tamminga, Carol A.
Pearlson, Godfrey D.
Clementz, Brett A.
Keshavan, Matcheri S.
Gershon, Elliot S.
Sweeney, John A.
Bishop, Jeffrey R.
Inflammation subtypes in psychosis and their relationships with genetic risk for psychiatric and cardiometabolic disorders
title Inflammation subtypes in psychosis and their relationships with genetic risk for psychiatric and cardiometabolic disorders
title_full Inflammation subtypes in psychosis and their relationships with genetic risk for psychiatric and cardiometabolic disorders
title_fullStr Inflammation subtypes in psychosis and their relationships with genetic risk for psychiatric and cardiometabolic disorders
title_full_unstemmed Inflammation subtypes in psychosis and their relationships with genetic risk for psychiatric and cardiometabolic disorders
title_short Inflammation subtypes in psychosis and their relationships with genetic risk for psychiatric and cardiometabolic disorders
title_sort inflammation subtypes in psychosis and their relationships with genetic risk for psychiatric and cardiometabolic disorders
topic Full Length Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9046804/
https://www.ncbi.nlm.nih.gov/pubmed/35496776
http://dx.doi.org/10.1016/j.bbih.2022.100459
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