Hepatic TGFβr1 Deficiency Attenuates Lipopolysaccharide/D-Galactosamine–Induced Acute Liver Failure Through Inhibiting GSK3β–Nrf2–Mediated Hepatocyte Apoptosis and Ferroptosis

BACKGROUND & AIMS: Acute liver failure (ALF) is a condition with high mortality and morbidity, characterized by glutathione depletion, oxidative stress, and mitochondrial dysfunction. Ferroptosis may be involved in ALF. Indeed, emerging studies have shown that ferroptosis plays a significant rol...

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Detalles Bibliográficos
Autores principales: Huang, Sha, Wang, Yuhua, Xie, Shunwen, Lai, Yuqi, Mo, Chan, Zeng, Ting, Kuang, Shanshan, Deng, Guanghui, Zhou, Chuying, Chen, Yuyao, Huang, Shaohui, Gao, Lei, Lv, Zhiping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9046809/
https://www.ncbi.nlm.nih.gov/pubmed/35202887
http://dx.doi.org/10.1016/j.jcmgh.2022.02.009

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