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Mcl-1 levels critically impact the sensitivities of human colorectal cancer cells to APG-1252-M1, a novel Bcl-2/Bcl-X(L) dual inhibitor that induces Bax-dependent apoptosis

New treatment options, such as targeted therapies, are urgently needed for the treatment of colorectal cancer (CRC), the third leading cause of cancer-related deaths worldwide. The current study focuses on demonstrating the therapeutic efficacies of APG-1252-M1 (an active form of the prodrug, APG-12...

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Detalles Bibliográficos
Autores principales:	Yao, Weilong, Bai, Longchuan, Wang, Shaomeng, Zha, Yifan, Sun, Shi-Yong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Neoplasia Press 2022
Materias:	Original article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9046866/ https://www.ncbi.nlm.nih.gov/pubmed/35462114 http://dx.doi.org/10.1016/j.neo.2022.100798

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