Cargando…

Hypothalamic Irak4 is a genetically controlled regulator of hypoglycemia-induced glucagon secretion

OBJECTIVES: Glucagon secretion to stimulate hepatic glucose production is the first line of defense against hypoglycemia. This response is triggered by so far incompletely characterized central hypoglycemia-sensing mechanisms, which control autonomous nervous activity and hormone secretion. The obje...

Descripción completa

Detalles Bibliográficos
Autores principales:	Picard, Alexandre, Berney, Xavier, Castillo-Armengol, Judit, Tarussio, David, Jan, Maxime, Sanchez-Archidona, Ana Rodriguez, Croizier, Sophie, Thorens, Bernard
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9046887/ https://www.ncbi.nlm.nih.gov/pubmed/35339728 http://dx.doi.org/10.1016/j.molmet.2022.101479

Ejemplares similares

Fgf15 Neurons of the Dorsomedial Hypothalamus Control Glucagon Secretion and Hepatic Gluconeogenesis
por: Picard, Alexandre, et al.
Publicado: (2021)

Lipid biosynthesis enzyme Agpat5 in AgRP-neurons is required for insulin-induced hypoglycemia sensing and glucagon secretion
por: Strembitska, Anastasiya, et al.
Publicado: (2022)

A Genetic Screen Identifies Hypothalamic Fgf15 as a Regulator of Glucagon Secretion
por: Picard, Alexandre, et al.
Publicado: (2016)

Tmem117 in AVP neurons regulates the counterregulatory response to hypoglycemia
por: Gaspari, Sevasti, et al.
Publicado: (2023)

Klf6 protects β-cells against insulin resistance-induced dedifferentiation
por: Dumayne, Christopher, et al.
Publicado: (2020)

α-cell glucokinase suppresses glucose-regulated glucagon secretion
por: Basco, Davide, et al.
Publicado: (2018)

Structural and molecular characterization of paraventricular thalamic glucokinase‐expressing neuronal circuits in the mouse
por: Gaspari, Sevasti, et al.
Publicado: (2022)

Glucokinase neurons of the paraventricular nucleus of the thalamus sense glucose and decrease food consumption
por: Kessler, Sébastien, et al.
Publicado: (2021)

Neuronal regulation of glucagon secretion and gluconeogenesis
por: Thorens, Bernard
Publicado: (2022)

A genetic screen identifies Crat as a regulator of pancreatic beta-cell insulin secretion
por: Berdous, Dassine, et al.
Publicado: (2020)

EphrinB1 modulates glutamatergic inputs into POMC-expressing progenitors and controls glucose homeostasis
por: Gervais, Manon, et al.
Publicado: (2020)

Hypothalamic CDK4 regulates thermogenesis by modulating sympathetic innervation of adipose tissues
por: Castillo‐Armengol, Judit, et al.
Publicado: (2020)

Glucose responsive neurons of the paraventricular thalamus control sucrose-seeking behavior
por: Labouèbe, Gwenaël, et al.
Publicado: (2016)

Ontogeny of the Projections From the Dorsomedial Division of the Anterior Bed Nucleus of the Stria Terminalis to Hypothalamic Nuclei
por: Lanzillo, Marc, et al.
Publicado: (2021)

GLUT2 expression by glial fibrillary acidic protein-positive tanycytes is required for promoting feeding-response to fasting
por: Barahona, M. J., et al.
Publicado: (2022)

A New Role for Hypothalamic Glucose-Sensing Neurons in Hypoglycemia Unawareness
por: Fioramonti, Xavier
Publicado: (2023)

Therapeutic Use of Intranasal Glucagon: Resolution of Hypoglycemia
por: Pontiroli, Antonio E., et al.
Publicado: (2019)

Plac8 is required for White Adipocyte Differentiation in vitro and Cell Number Control in vivo
por: Jimenez-Preitner, Maria, et al.
Publicado: (2012)

GLP1 and glucagon co-secreting pancreatic neuroendocrine tumor presenting as hypoglycemia after gastric bypass
por: Guimarães, Marta, et al.
Publicado: (2015)

Hypothalamic Glucagon Receptors Regulate Feeding in Mice
por: Cunningham, Stephen E, et al.
Publicado: (2021)

Ventromedial Hypothalamic Nitric Oxide Production Is Necessary for Hypoglycemia Detection and Counterregulation
por: Fioramonti, Xavier, et al.
Publicado: (2010)

Restoration of the Hypothalamic-pituitary-adrenal Response to Hypoglycemia in Type 2 Diabetes by Avoiding Chronic Hypoglycemia
por: Tsuda, Shin-ichi, et al.
Publicado: (2016)

Treatment of severe diabetic hypoglycemia with glucagon: an underutilized therapeutic approach
por: Kedia, Nitil
Publicado: (2011)

Different Transcriptional Control of Metabolism and Extracellular Matrix in Visceral and Subcutaneous Fat of Obese and Rimonabant Treated Mice
por: Poussin, Carine, et al.
Publicado: (2008)

Ins1(Cre) knock-in mice for beta cell-specific gene recombination
por: Thorens, Bernard, et al.
Publicado: (2014)

Hypothalamic S-Nitrosylation Contributes to the Counter-Regulatory Response Impairment following Recurrent Hypoglycemia
por: Fioramonti, Xavier, et al.
Publicado: (2013)

Projections from the dorsomedial division of the bed nucleus of the stria terminalis to hypothalamic nuclei in the mouse
por: Barbier, Marie, et al.
Publicado: (2020)

A case of hypothalamic hypopituitarism accompanied by recurrent severe hypoglycemia
por: Takai, Maiko, et al.
Publicado: (2015)

Hypoglycemia-activated Hypothalamic Microglia Impairs Glucose Counterregulatory Responses
por: Winkler, Zsuzsanna, et al.
Publicado: (2019)

Irak : cinco años después /
por: Rosas, María Cristina
Publicado: (2008)

Use of glucagon in severe hypoglycemia is scarce in most countries, and has not been expanded by new ready-to-use glucagons
por: Pontiroli, Antonio E., et al.
Publicado: (2022)

Early Loss of the Glucagon Response to Hypoglycemia in Adolescents With Type 1 Diabetes
por: Siafarikas, Aris, et al.
Publicado: (2012)

A Potential Role for Endogenous Glucagon in Preventing Post-Bariatric Hypoglycemia
por: Lobato, Carolina B., et al.
Publicado: (2020)

IRAK1 and IRAK4 as emerging therapeutic targets in hematologic malignancies
por: Bennett, Joshua, et al.
Publicado: (2022)

A Parabrachial-Hypothalamic Cholecystokinin Neurocircuit Controls Counterregulatory Responses to Hypoglycemia
por: Garfield, Alastair S., et al.
Publicado: (2014)

Hypoglycemia: Role of Hypothalamic Glucose-Inhibited (GI) Neurons in Detection and Correction
por: Zhou, Chunxue, et al.
Publicado: (2018)

Development of Posterior Hypothalamic Neurons Enlightens a Switch in the Prosencephalic Basic Plan
por: Croizier, Sophie, et al.
Publicado: (2011)

Outgrowing IRAK-4
por: Bashyam, Hema
Publicado: (2007)

IRAK signalling in cancer
por: Rhyasen, G W, et al.
Publicado: (2015)

A glucagon analog chemically stabilized for immediate treatment of life-threatening hypoglycemia()
por: Chabenne, Joseph, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_abbm40gh4s5d0bs26o31sss320