The CtIP-CtBP1/2-HDAC1-AP1 transcriptional complex is required for the transrepression of DNA damage modulators in the pathogenesis of osteosarcoma

Most tumors, including osteosarcomas, have deficiencies in DNA damage repair. However, the regulatory mechanisms underlying dysregulation of DNA damage repair genes are still being investigated. In this study, we reveal that C-terminal binding protein (CtBP) interacting protein (CtIP) couples with t...

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Detalles Bibliográficos
Autores principales: Chen, Xun, Zhang, Qian, Dang, Xiaoqian, Fan, Jinzhu, Song, Tao, Li, Zhong, Duan, Ning, Zhang, Wentao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9047009/
https://www.ncbi.nlm.nih.gov/pubmed/35452995
http://dx.doi.org/10.1016/j.tranon.2022.101429

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