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An analogue of a kinase inhibitor exhibits subjective characteristics that contribute to its inhibitory activities as a potential anti-cancer candidate: insights through computational biomolecular modelling of UM-164 binding with lyn protein

The recent emergence of lyn kinase as a driver of aggressive behaviour in triple-negative breast cancer (TNBC) remains a major concern posing a burden for people living with breast cancer and drug development. The binding of UM-164 to lyn protein has been noted to impact the conformational dynamics...

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Detalles Bibliográficos
Autores principales: Ndagi, Umar, Abdullahi, Maryam, Hamza, Asmau N., Soliman, Mahmoud E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9047091/
https://www.ncbi.nlm.nih.gov/pubmed/35492550
http://dx.doi.org/10.1039/c9ra07204g

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