Longitudinal Analysis of SARS-CoV-2 Vaccine Breakthrough Infections Reveals Limited Infectious Virus Shedding and Restricted Tissue Distribution

BACKGROUND: The global effort to vaccinate people against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) during an ongoing pandemic has raised questions about how vaccine breakthrough infections compare with infections in immunologically naive individuals and the potential for vaccinat...

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Autores principales: Ke, Ruian, Martinez, Pamela P, Smith, Rebecca L, Gibson, Laura L, Achenbach, Chad J, McFall, Sally, Qi, Chao, Jacob, Joshua, Dembele, Etienne, Bundy, Camille, Simons, Lacy M, Ozer, Egon A, Hultquist, Judd F, Lorenzo-Redondo, Ramon, Opdycke, Anita K, Hawkins, Claudia, Murphy, Robert L, Mirza, Agha, Conte, Madison, Gallagher, Nicholas, Luo, Chun Huai, Jarrett, Junko, Conte, Abigail, Zhou, Ruifeng, Farjo, Mireille, Rendon, Gloria, Fields, Christopher J, Wang, Leyi, Fredrickson, Richard, Baughman, Melinda E, Chiu, Karen K, Choi, Hannah, Scardina, Kevin R, Owens, Alyssa N, Broach, John, Barton, Bruce, Lazar, Peter, Robinson, Matthew L, Mostafa, Heba H, Manabe, Yukari C, Pekosz, Andrew, McManus, David D, Brooke, Christopher B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Major Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9047214/
https://www.ncbi.nlm.nih.gov/pubmed/35791353
http://dx.doi.org/10.1093/ofid/ofac192
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author Ke, Ruian
Martinez, Pamela P
Smith, Rebecca L
Gibson, Laura L
Achenbach, Chad J
McFall, Sally
Qi, Chao
Jacob, Joshua
Dembele, Etienne
Bundy, Camille
Simons, Lacy M
Ozer, Egon A
Hultquist, Judd F
Lorenzo-Redondo, Ramon
Opdycke, Anita K
Hawkins, Claudia
Murphy, Robert L
Mirza, Agha
Conte, Madison
Gallagher, Nicholas
Luo, Chun Huai
Jarrett, Junko
Conte, Abigail
Zhou, Ruifeng
Farjo, Mireille
Rendon, Gloria
Fields, Christopher J
Wang, Leyi
Fredrickson, Richard
Baughman, Melinda E
Chiu, Karen K
Choi, Hannah
Scardina, Kevin R
Owens, Alyssa N
Broach, John
Barton, Bruce
Lazar, Peter
Robinson, Matthew L
Mostafa, Heba H
Manabe, Yukari C
Pekosz, Andrew
McManus, David D
Brooke, Christopher B
author_facet Ke, Ruian
Martinez, Pamela P
Smith, Rebecca L
Gibson, Laura L
Achenbach, Chad J
McFall, Sally
Qi, Chao
Jacob, Joshua
Dembele, Etienne
Bundy, Camille
Simons, Lacy M
Ozer, Egon A
Hultquist, Judd F
Lorenzo-Redondo, Ramon
Opdycke, Anita K
Hawkins, Claudia
Murphy, Robert L
Mirza, Agha
Conte, Madison
Gallagher, Nicholas
Luo, Chun Huai
Jarrett, Junko
Conte, Abigail
Zhou, Ruifeng
Farjo, Mireille
Rendon, Gloria
Fields, Christopher J
Wang, Leyi
Fredrickson, Richard
Baughman, Melinda E
Chiu, Karen K
Choi, Hannah
Scardina, Kevin R
Owens, Alyssa N
Broach, John
Barton, Bruce
Lazar, Peter
Robinson, Matthew L
Mostafa, Heba H
Manabe, Yukari C
Pekosz, Andrew
McManus, David D
Brooke, Christopher B
author_sort Ke, Ruian
collection PubMed
description BACKGROUND: The global effort to vaccinate people against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) during an ongoing pandemic has raised questions about how vaccine breakthrough infections compare with infections in immunologically naive individuals and the potential for vaccinated individuals to transmit the virus. METHODS: We examined viral dynamics and infectious virus shedding through daily longitudinal sampling in 23 adults infected with SARS-CoV-2 at varying stages of vaccination, including 6 fully vaccinated individuals. RESULTS: The durations of both infectious virus shedding and symptoms were significantly reduced in vaccinated individuals compared with unvaccinated individuals. We also observed that breakthrough infections are associated with strong tissue compartmentalization and are only detectable in saliva in some cases. CONCLUSIONS: Vaccination shortens the duration of time of high transmission potential, minimizes symptom duration, and may restrict tissue dissemination.
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spelling pubmed-90472142022-04-28 Longitudinal Analysis of SARS-CoV-2 Vaccine Breakthrough Infections Reveals Limited Infectious Virus Shedding and Restricted Tissue Distribution Ke, Ruian Martinez, Pamela P Smith, Rebecca L Gibson, Laura L Achenbach, Chad J McFall, Sally Qi, Chao Jacob, Joshua Dembele, Etienne Bundy, Camille Simons, Lacy M Ozer, Egon A Hultquist, Judd F Lorenzo-Redondo, Ramon Opdycke, Anita K Hawkins, Claudia Murphy, Robert L Mirza, Agha Conte, Madison Gallagher, Nicholas Luo, Chun Huai Jarrett, Junko Conte, Abigail Zhou, Ruifeng Farjo, Mireille Rendon, Gloria Fields, Christopher J Wang, Leyi Fredrickson, Richard Baughman, Melinda E Chiu, Karen K Choi, Hannah Scardina, Kevin R Owens, Alyssa N Broach, John Barton, Bruce Lazar, Peter Robinson, Matthew L Mostafa, Heba H Manabe, Yukari C Pekosz, Andrew McManus, David D Brooke, Christopher B Open Forum Infect Dis Major Article BACKGROUND: The global effort to vaccinate people against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) during an ongoing pandemic has raised questions about how vaccine breakthrough infections compare with infections in immunologically naive individuals and the potential for vaccinated individuals to transmit the virus. METHODS: We examined viral dynamics and infectious virus shedding through daily longitudinal sampling in 23 adults infected with SARS-CoV-2 at varying stages of vaccination, including 6 fully vaccinated individuals. RESULTS: The durations of both infectious virus shedding and symptoms were significantly reduced in vaccinated individuals compared with unvaccinated individuals. We also observed that breakthrough infections are associated with strong tissue compartmentalization and are only detectable in saliva in some cases. CONCLUSIONS: Vaccination shortens the duration of time of high transmission potential, minimizes symptom duration, and may restrict tissue dissemination. Oxford University Press 2022-04-13 /pmc/articles/PMC9047214/ /pubmed/35791353 http://dx.doi.org/10.1093/ofid/ofac192 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Major Article
Ke, Ruian
Martinez, Pamela P
Smith, Rebecca L
Gibson, Laura L
Achenbach, Chad J
McFall, Sally
Qi, Chao
Jacob, Joshua
Dembele, Etienne
Bundy, Camille
Simons, Lacy M
Ozer, Egon A
Hultquist, Judd F
Lorenzo-Redondo, Ramon
Opdycke, Anita K
Hawkins, Claudia
Murphy, Robert L
Mirza, Agha
Conte, Madison
Gallagher, Nicholas
Luo, Chun Huai
Jarrett, Junko
Conte, Abigail
Zhou, Ruifeng
Farjo, Mireille
Rendon, Gloria
Fields, Christopher J
Wang, Leyi
Fredrickson, Richard
Baughman, Melinda E
Chiu, Karen K
Choi, Hannah
Scardina, Kevin R
Owens, Alyssa N
Broach, John
Barton, Bruce
Lazar, Peter
Robinson, Matthew L
Mostafa, Heba H
Manabe, Yukari C
Pekosz, Andrew
McManus, David D
Brooke, Christopher B
Longitudinal Analysis of SARS-CoV-2 Vaccine Breakthrough Infections Reveals Limited Infectious Virus Shedding and Restricted Tissue Distribution
title Longitudinal Analysis of SARS-CoV-2 Vaccine Breakthrough Infections Reveals Limited Infectious Virus Shedding and Restricted Tissue Distribution
title_full Longitudinal Analysis of SARS-CoV-2 Vaccine Breakthrough Infections Reveals Limited Infectious Virus Shedding and Restricted Tissue Distribution
title_fullStr Longitudinal Analysis of SARS-CoV-2 Vaccine Breakthrough Infections Reveals Limited Infectious Virus Shedding and Restricted Tissue Distribution
title_full_unstemmed Longitudinal Analysis of SARS-CoV-2 Vaccine Breakthrough Infections Reveals Limited Infectious Virus Shedding and Restricted Tissue Distribution
title_short Longitudinal Analysis of SARS-CoV-2 Vaccine Breakthrough Infections Reveals Limited Infectious Virus Shedding and Restricted Tissue Distribution
title_sort longitudinal analysis of sars-cov-2 vaccine breakthrough infections reveals limited infectious virus shedding and restricted tissue distribution
topic Major Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9047214/
https://www.ncbi.nlm.nih.gov/pubmed/35791353
http://dx.doi.org/10.1093/ofid/ofac192
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