Phytochemicals targeting Toll-like receptors 4 (TLR4) in inflammatory bowel disease

Inflammatory bowel disease (IBD) is a collective term for inflammatory diseases including Crohn’s disease and ulcerative colitis. Toll-like receptor 4 (TLR4) is thought to play a key role in the pathogenesis of IBD. Inhibition of TLR4 has been recognized as an effective target for the treatment of I...

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Autores principales: Dai, Wenbin, Long, Longhai, Wang, Xiaoqiang, Li, Sen, Xu, Houping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9047385/
https://www.ncbi.nlm.nih.gov/pubmed/35484567
http://dx.doi.org/10.1186/s13020-022-00611-w
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author Dai, Wenbin
Long, Longhai
Wang, Xiaoqiang
Li, Sen
Xu, Houping
author_facet Dai, Wenbin
Long, Longhai
Wang, Xiaoqiang
Li, Sen
Xu, Houping
author_sort Dai, Wenbin
collection PubMed
description Inflammatory bowel disease (IBD) is a collective term for inflammatory diseases including Crohn’s disease and ulcerative colitis. Toll-like receptor 4 (TLR4) is thought to play a key role in the pathogenesis of IBD. Inhibition of TLR4 has been recognized as an effective target for the treatment of IBD. Many phytochemicals have been shown to have potential as new drugs for the treatment of IBD. This review surveyed the available literature and reports which focused on the in vivo effects of phytochemicals targeting TLR4 in different models of IBD, and clarified the significance of TLR4 as a current therapeutic target for IBD. Based on our review, we have concluded that phytochemicals targeting TLR4 are potentially effective candidates for developing new therapeutic drugs against IBD.
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spelling pubmed-90473852022-04-29 Phytochemicals targeting Toll-like receptors 4 (TLR4) in inflammatory bowel disease Dai, Wenbin Long, Longhai Wang, Xiaoqiang Li, Sen Xu, Houping Chin Med Review Inflammatory bowel disease (IBD) is a collective term for inflammatory diseases including Crohn’s disease and ulcerative colitis. Toll-like receptor 4 (TLR4) is thought to play a key role in the pathogenesis of IBD. Inhibition of TLR4 has been recognized as an effective target for the treatment of IBD. Many phytochemicals have been shown to have potential as new drugs for the treatment of IBD. This review surveyed the available literature and reports which focused on the in vivo effects of phytochemicals targeting TLR4 in different models of IBD, and clarified the significance of TLR4 as a current therapeutic target for IBD. Based on our review, we have concluded that phytochemicals targeting TLR4 are potentially effective candidates for developing new therapeutic drugs against IBD. BioMed Central 2022-04-28 /pmc/articles/PMC9047385/ /pubmed/35484567 http://dx.doi.org/10.1186/s13020-022-00611-w Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Dai, Wenbin
Long, Longhai
Wang, Xiaoqiang
Li, Sen
Xu, Houping
Phytochemicals targeting Toll-like receptors 4 (TLR4) in inflammatory bowel disease
title Phytochemicals targeting Toll-like receptors 4 (TLR4) in inflammatory bowel disease
title_full Phytochemicals targeting Toll-like receptors 4 (TLR4) in inflammatory bowel disease
title_fullStr Phytochemicals targeting Toll-like receptors 4 (TLR4) in inflammatory bowel disease
title_full_unstemmed Phytochemicals targeting Toll-like receptors 4 (TLR4) in inflammatory bowel disease
title_short Phytochemicals targeting Toll-like receptors 4 (TLR4) in inflammatory bowel disease
title_sort phytochemicals targeting toll-like receptors 4 (tlr4) in inflammatory bowel disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9047385/
https://www.ncbi.nlm.nih.gov/pubmed/35484567
http://dx.doi.org/10.1186/s13020-022-00611-w
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AT wangxiaoqiang phytochemicalstargetingtolllikereceptors4tlr4ininflammatoryboweldisease
AT lisen phytochemicalstargetingtolllikereceptors4tlr4ininflammatoryboweldisease
AT xuhouping phytochemicalstargetingtolllikereceptors4tlr4ininflammatoryboweldisease

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