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Coupling Anion Exchange Chromatography with Native Mass Spectrometry for Charge Heterogeneity Characterization of Monoclonal Antibodies

[Image: see text] Despite the recent success of coupling anion exchange chromatography with native mass spectrometry (AEX-MS) to study anionic proteins, the utility of AEX-MS methods in therapeutic monoclonal antibody (mAb) characterization has been limited. In this work, we developed and optimized...

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Detalles Bibliográficos
Autores principales:	Liu, Anita P., Yan, Yuetian, Wang, Shunhai, Li, Ning
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2022
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9047409/ https://www.ncbi.nlm.nih.gov/pubmed/35420790 http://dx.doi.org/10.1021/acs.analchem.2c00707

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