The oxidation of (−)-epigallocatechin-3-gallate inhibits T-cell acute lymphoblastic leukemia cell line HPB-ALL via the regulation of Notch1 expression

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy, and commonly associated with activating mutations in the Notch1 pathway. (−)-Epigallocatechin-3-gallate (EGCG) is the most abundant and active catechin and has been shown to regulate Notch signaling. Taking into a...

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Detalles Bibliográficos
Autores principales: Wang, Yu-Na, Wang, Jing, Yang, Hao-Nan, Zhang, Bang-Lei, Zhang, Pan, Sun, Pei-Yuan, Zhang, Nin, Wang, Ya, Sheng, Jun, Wang, Xuan-Jun, Zi, Cheng-Ting
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9047518/
https://www.ncbi.nlm.nih.gov/pubmed/35494663
http://dx.doi.org/10.1039/c9ra08459b

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