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Asymptomatic and pre-symptomatic infection in Coronavirus Disease 2019 pandemic

With the presence of Coronavirus Disease 2019 (COVID-19) asymptomatic infections detected, their proportion, transmission potential, and other aspects such as immunity and related emerging challenges have attracted people’s attention. We have found that based on high-quality research, asymptomatic i...

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Autores principales: Wang, Yutong, Zheng, Ke, Gao, Wenjing, Lv, Jun, Yu, Canqing, Wang, Lan, Wang, Zijun, Wang, Bo, Liao, Chunxiao, Li, Liming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: De Gruyter 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9047649/
https://www.ncbi.nlm.nih.gov/pubmed/35658110
http://dx.doi.org/10.1515/mr-2021-0034
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author Wang, Yutong
Zheng, Ke
Gao, Wenjing
Lv, Jun
Yu, Canqing
Wang, Lan
Wang, Zijun
Wang, Bo
Liao, Chunxiao
Li, Liming
author_facet Wang, Yutong
Zheng, Ke
Gao, Wenjing
Lv, Jun
Yu, Canqing
Wang, Lan
Wang, Zijun
Wang, Bo
Liao, Chunxiao
Li, Liming
author_sort Wang, Yutong
collection PubMed
description With the presence of Coronavirus Disease 2019 (COVID-19) asymptomatic infections detected, their proportion, transmission potential, and other aspects such as immunity and related emerging challenges have attracted people’s attention. We have found that based on high-quality research, asymptomatic infections account for at least one-third of the total cases, whereas based on systematic review and meta-analysis, the proportion is about one-fifth. Evaluating the true transmission potential of asymptomatic cases is difficult but critical, since it may affect national policies in response to COVID-19. We have summarized the current evidence and found, compared with symptomatic cases, the transmission capacity of asymptomatic individuals is weaker, even though they have similar viral load and relatively short virus shedding duration. As the outbreak progresses, asymptomatic infections have also been found to develop long COVID-19. In addition, the role of asymptomatic infection in COVID-19 remains to be further revealed as the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants continue to emerge. Nevertheless, as asymptomatic infections transmit the SARS-CoV-2 virus silently, they still pose a substantial threat to public health. Therefore, it is essential to conduct screening to obtain more knowledge about the asymptomatic infections and to detect them as soon as possible; meanwhile, management of them is also a key point in the fight against COVID-19 community transmission. The different management of asymptomatic infections in various countries are compared and the experience in China is displayed in detail.
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spelling pubmed-90476492022-06-04 Asymptomatic and pre-symptomatic infection in Coronavirus Disease 2019 pandemic Wang, Yutong Zheng, Ke Gao, Wenjing Lv, Jun Yu, Canqing Wang, Lan Wang, Zijun Wang, Bo Liao, Chunxiao Li, Liming Med Rev (Berl) Review With the presence of Coronavirus Disease 2019 (COVID-19) asymptomatic infections detected, their proportion, transmission potential, and other aspects such as immunity and related emerging challenges have attracted people’s attention. We have found that based on high-quality research, asymptomatic infections account for at least one-third of the total cases, whereas based on systematic review and meta-analysis, the proportion is about one-fifth. Evaluating the true transmission potential of asymptomatic cases is difficult but critical, since it may affect national policies in response to COVID-19. We have summarized the current evidence and found, compared with symptomatic cases, the transmission capacity of asymptomatic individuals is weaker, even though they have similar viral load and relatively short virus shedding duration. As the outbreak progresses, asymptomatic infections have also been found to develop long COVID-19. In addition, the role of asymptomatic infection in COVID-19 remains to be further revealed as the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants continue to emerge. Nevertheless, as asymptomatic infections transmit the SARS-CoV-2 virus silently, they still pose a substantial threat to public health. Therefore, it is essential to conduct screening to obtain more knowledge about the asymptomatic infections and to detect them as soon as possible; meanwhile, management of them is also a key point in the fight against COVID-19 community transmission. The different management of asymptomatic infections in various countries are compared and the experience in China is displayed in detail. De Gruyter 2022-02-24 /pmc/articles/PMC9047649/ /pubmed/35658110 http://dx.doi.org/10.1515/mr-2021-0034 Text en © 2022 Yutong Wang et al., published by De Gruyter, Berlin/Boston https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
spellingShingle Review
Wang, Yutong
Zheng, Ke
Gao, Wenjing
Lv, Jun
Yu, Canqing
Wang, Lan
Wang, Zijun
Wang, Bo
Liao, Chunxiao
Li, Liming
Asymptomatic and pre-symptomatic infection in Coronavirus Disease 2019 pandemic
title Asymptomatic and pre-symptomatic infection in Coronavirus Disease 2019 pandemic
title_full Asymptomatic and pre-symptomatic infection in Coronavirus Disease 2019 pandemic
title_fullStr Asymptomatic and pre-symptomatic infection in Coronavirus Disease 2019 pandemic
title_full_unstemmed Asymptomatic and pre-symptomatic infection in Coronavirus Disease 2019 pandemic
title_short Asymptomatic and pre-symptomatic infection in Coronavirus Disease 2019 pandemic
title_sort asymptomatic and pre-symptomatic infection in coronavirus disease 2019 pandemic
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9047649/
https://www.ncbi.nlm.nih.gov/pubmed/35658110
http://dx.doi.org/10.1515/mr-2021-0034
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