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Robust, Durable Gene Activation In Vivo via mRNA-Encoded Activators

[Image: see text] Programmable control of gene expression via nuclease-null Cas9 fusion proteins has enabled the engineering of cellular behaviors. Here, both transcriptional and epigenetic gene activation via synthetic mRNA and lipid nanoparticle delivery was demonstrated in vivo. These highly effi...

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Detalles Bibliográficos
Autores principales:	Beyersdorf, Jared P., Bawage, Swapnil, Iglesias, Nahid, Peck, Hannah E., Hobbs, Ryan A., Wroe, Jay A., Zurla, Chiara, Gersbach, Charles A., Santangelo, Philip J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2022
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9047660/ https://www.ncbi.nlm.nih.gov/pubmed/35357116 http://dx.doi.org/10.1021/acsnano.1c10631

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