Acidic Microenvironments Found in Cutaneous Leishmania Lesions Curtail NO-Dependent Antiparasitic Macrophage Activity

Local tissue acidosis affects anti-tumor immunity. In contrast, data on tissue pH levels in infected tissues and their impact on antimicrobial activity is sparse. In this study, we assessed the pH levels in cutaneous Leishmania lesions. Leishmania major-infected skin tissue displayed pH levels of 6....

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Detalles Bibliográficos
Autores principales: Frick, Linus, Hinterland, Linda, Renner, Kathrin, Vogl, Marion, Babl, Nathalie, Heckscher, Simon, Weigert, Anna, Weiß, Susanne, Gläsner, Joachim, Berger, Raffaela, Oefner, Peter J., Dettmer, Katja, Kreutz, Marina, Schatz, Valentin, Jantsch, Jonathan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9047701/
https://www.ncbi.nlm.nih.gov/pubmed/35493523
http://dx.doi.org/10.3389/fimmu.2022.789366

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