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Associations Between Vertebral Marrow Proton Density Fat Fraction and Risk of Prostate Cancer

Bone marrow adipocytes may be responsible for cancer progression. Although marrow adipogenesis is suspected to be involved in prostate carcinogenesis, an association between marrow adiposity and prostate cancer risk has not been clearly established in vivo. This work included 115 newly diagnosed cas...

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Autores principales: Li, Shaojun, Wang, Bo, Liang, Wenwen, Chen, Qi, Wang, Wei, Mei, Jiangjun, Zhang, He, Liu, Qianqian, Yuan, Mingyuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9047738/
https://www.ncbi.nlm.nih.gov/pubmed/35498437
http://dx.doi.org/10.3389/fendo.2022.874904
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author Li, Shaojun
Wang, Bo
Liang, Wenwen
Chen, Qi
Wang, Wei
Mei, Jiangjun
Zhang, He
Liu, Qianqian
Yuan, Mingyuan
author_facet Li, Shaojun
Wang, Bo
Liang, Wenwen
Chen, Qi
Wang, Wei
Mei, Jiangjun
Zhang, He
Liu, Qianqian
Yuan, Mingyuan
author_sort Li, Shaojun
collection PubMed
description Bone marrow adipocytes may be responsible for cancer progression. Although marrow adipogenesis is suspected to be involved in prostate carcinogenesis, an association between marrow adiposity and prostate cancer risk has not been clearly established in vivo. This work included 115 newly diagnosed cases of histologically confirmed prostate cancer (range, 48–79 years) and 87 age-matched healthy controls. Marrow proton density fat fraction (PDFF) was measured by 3.0-T MR spectroscopy at the spine lumbar. Associations between marrow PDFF and risk of prostate cancer by stage of disease and grade sub-types were performed using multivariable polytomous logistic regression. There were no significant group differences in the vertebral marrow PDFF, despite prostate cancer patients having 6.6% higher marrow PDFF compared to the healthy controls (61.7 ± 9.8% vs. 57.9 ± 6.5%; t = 1.429, p = 0.161). After adjusting for various clinical and demographic characteristics, we found that elevated marrow PDFF was related to an increased risk of high-grade prostate cancer [odds ratios (OR) = 1.31; 95% confidence interval (CI), 1.08–1.57; p = 0.003]. Likewise, increased marrow PDFF had a significantly positive correlation with aggressive prostate cancer risk (OR = 1.54; 95% CI, 1.13–1.92; p <0.001). There were no associations between marrow PDFF and low-grade (p = 0.314) or non-aggressive (p = 0.435) prostate cancer risk. The data support the hypothesis that marrow adiposity was correlated with increased risk of aggressive prostate cancer, supporting a link between adipogenesis and prostate cancer risk.
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spelling pubmed-90477382022-04-29 Associations Between Vertebral Marrow Proton Density Fat Fraction and Risk of Prostate Cancer Li, Shaojun Wang, Bo Liang, Wenwen Chen, Qi Wang, Wei Mei, Jiangjun Zhang, He Liu, Qianqian Yuan, Mingyuan Front Endocrinol (Lausanne) Endocrinology Bone marrow adipocytes may be responsible for cancer progression. Although marrow adipogenesis is suspected to be involved in prostate carcinogenesis, an association between marrow adiposity and prostate cancer risk has not been clearly established in vivo. This work included 115 newly diagnosed cases of histologically confirmed prostate cancer (range, 48–79 years) and 87 age-matched healthy controls. Marrow proton density fat fraction (PDFF) was measured by 3.0-T MR spectroscopy at the spine lumbar. Associations between marrow PDFF and risk of prostate cancer by stage of disease and grade sub-types were performed using multivariable polytomous logistic regression. There were no significant group differences in the vertebral marrow PDFF, despite prostate cancer patients having 6.6% higher marrow PDFF compared to the healthy controls (61.7 ± 9.8% vs. 57.9 ± 6.5%; t = 1.429, p = 0.161). After adjusting for various clinical and demographic characteristics, we found that elevated marrow PDFF was related to an increased risk of high-grade prostate cancer [odds ratios (OR) = 1.31; 95% confidence interval (CI), 1.08–1.57; p = 0.003]. Likewise, increased marrow PDFF had a significantly positive correlation with aggressive prostate cancer risk (OR = 1.54; 95% CI, 1.13–1.92; p <0.001). There were no associations between marrow PDFF and low-grade (p = 0.314) or non-aggressive (p = 0.435) prostate cancer risk. The data support the hypothesis that marrow adiposity was correlated with increased risk of aggressive prostate cancer, supporting a link between adipogenesis and prostate cancer risk. Frontiers Media S.A. 2022-04-14 /pmc/articles/PMC9047738/ /pubmed/35498437 http://dx.doi.org/10.3389/fendo.2022.874904 Text en Copyright © 2022 Li, Wang, Liang, Chen, Wang, Mei, Zhang, Liu and Yuan https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Li, Shaojun
Wang, Bo
Liang, Wenwen
Chen, Qi
Wang, Wei
Mei, Jiangjun
Zhang, He
Liu, Qianqian
Yuan, Mingyuan
Associations Between Vertebral Marrow Proton Density Fat Fraction and Risk of Prostate Cancer
title Associations Between Vertebral Marrow Proton Density Fat Fraction and Risk of Prostate Cancer
title_full Associations Between Vertebral Marrow Proton Density Fat Fraction and Risk of Prostate Cancer
title_fullStr Associations Between Vertebral Marrow Proton Density Fat Fraction and Risk of Prostate Cancer
title_full_unstemmed Associations Between Vertebral Marrow Proton Density Fat Fraction and Risk of Prostate Cancer
title_short Associations Between Vertebral Marrow Proton Density Fat Fraction and Risk of Prostate Cancer
title_sort associations between vertebral marrow proton density fat fraction and risk of prostate cancer
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9047738/
https://www.ncbi.nlm.nih.gov/pubmed/35498437
http://dx.doi.org/10.3389/fendo.2022.874904
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