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Targeted Protein Degradation: An Important Tool for Drug Discovery for “Undruggable” Tumor Transcription Factors

Conventional small-molecule drugs (SMDs) are compounds characterized by low molecular weight, high cell permeability, and high selectivity. In clinical translation, SMDs are regarded as good candidates for oral drug formulation. SMD inhibitors play an important role in cancer treatment; however, res...

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Detalles Bibliográficos
Autores principales: Dai, Mengyuan, Radhakrishnan, Sridhar, Li, Rui, Tan, Ruirong, Yan, Kuo, Fan, Gang, Liu, Miao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9047787/
https://www.ncbi.nlm.nih.gov/pubmed/35466792
http://dx.doi.org/10.1177/15330338221095950