A high-throughput bioanalytical assay to support pharmacokinetic interaction study of oxycodone and diazepam in Sprague Dawley rats

Benzodiazepines potentiate respiratory depression when combined with an opioid leading the U.S Food and Drug Administration (FDA) to recommend updating the labels of these products with a boxed warning for respiratory depression with co-use. Potential respiratory depression upon co-administration of...

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Detalles Bibliográficos
Autores principales: Pilli, Nageswara R., Narayanasamy, Suresh, Xu, Lin, Chockalingam, Ashok, Shea, Katherine I., Stewart, Sharron, Rouse, Rodney, Patel, Vikram, Matta, Murali K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9047970/
https://www.ncbi.nlm.nih.gov/pubmed/35494453
http://dx.doi.org/10.1039/c9ra05785d

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