Low doses of niclosamide and quinacrine combination yields synergistic effect in melanoma via activating autophagy-mediated p53-dependent apoptosis

Malignant melanoma is a highly aggressive, malignant, and drug-resistant tumor. It lacks an efficient treatment approach. In this study, we developed a novel anti-melanoma strategy by using anti-tapeworm drug niclosamide and anti-malarial drug quinacrine, and investigated the molecular mechanism by...

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Detalles Bibliográficos
Autores principales: Zheng, Xuan, Zhang, Jianyun, Li, Shuangting, Gao, Xiaolei, Zhang, Yixin, Wang, Meng, Dong, Liying, Sun, Liangjie, Zhao, Na, Ma, Zeyun, Ding, Chong, Wang, Yixiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9048101/
https://www.ncbi.nlm.nih.gov/pubmed/35460941
http://dx.doi.org/10.1016/j.tranon.2022.101425

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