Autotaxin signaling facilitates β cell dedifferentiation and dysfunction induced by Sirtuin 3 deficiency

OBJECTIVE: β cell dedifferentiation may underlie the reversible reduction in pancreatic β cell mass and function in type 2 diabetes (T2D). We previously reported that β cell-specific Sirt3 knockout (Sirt3(f/f;Cre/+)) mice developed impaired glucose tolerance and glucose-stimulated insulin secretion...

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Detalles Bibliográficos
Autores principales: Cao, Huanyi, Chung, Arthur C.K., Ming, Xing, Mao, Dandan, Lee, Heung Man, Cao, Xiaoyun, Rutter, Guy A., Chan, Juliana C.N., Tian, Xiao Yu, Kong, Alice P.S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9048116/
https://www.ncbi.nlm.nih.gov/pubmed/35398277
http://dx.doi.org/10.1016/j.molmet.2022.101493

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