GRK5 is an essential co-repressor of the cardiac mineralocorticoid receptor and is selectively induced by finerenone

BACKGROUND: In the heart, aldosterone (Aldo) binds the mineralocorticoid receptor (MR) to exert damaging, adverse remodeling-promoting effects. We recently showed that G protein-coupled receptor-kinase (GRK)-5 blocks the cardiac MR by directly phosphorylating it, thereby repressing its transcription...

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Detalles Bibliográficos
Autores principales: Pollard, Celina M, Suster, Malka S, Cora, Natalie, Carbone, Alexandra M, Lymperopoulos, Anastasios
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2022
Materias:
Basic Study
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9048278/
https://www.ncbi.nlm.nih.gov/pubmed/35582468
http://dx.doi.org/10.4330/wjc.v14.i4.220

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9048278/
https://www.ncbi.nlm.nih.gov/pubmed/35582468
http://dx.doi.org/10.4330/wjc.v14.i4.220

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