TDP-43 Oligomerization and Phase Separation Properties Are Necessary for Autoregulation

Loss of TDP-43 protein homeostasis and dysfunction, in particular TDP-43 aggregation, are tied to amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). TDP-43 is an RNA binding protein tightly controlling its own expression levels through a negative feedback loop, involving TDP-43 r...

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Detalles Bibliográficos
Autores principales: Koehler, Lydia C., Grese, Zachary R., Bastos, Alliny C. S., Mamede, Lohany D., Heyduk, Tomasz, Ayala, Yuna M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9048411/
https://www.ncbi.nlm.nih.gov/pubmed/35495061
http://dx.doi.org/10.3389/fnins.2022.818655

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