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Three-dimensionally printed polylactic acid/cellulose acetate scaffolds with antimicrobial effect

This study aimed to develop novel, biodegradable, antiseptic-loaded and low-cost scaffolds using a direct ink writing (DIW) technique for antibacterial applications. Polylactic acid/cellulose acetate (PLA/CA) mixtures with different composition ratios were prepared, and the effect of CA content on t...

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Autores principales: Zuo, Mengdi, Pan, Nengyu, Liu, Quanjing, Ren, Xuehong, Liu, Yu, Huang, Tung-Shi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9048423/
https://www.ncbi.nlm.nih.gov/pubmed/35496135
http://dx.doi.org/10.1039/c9ra08916k
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author Zuo, Mengdi
Pan, Nengyu
Liu, Quanjing
Ren, Xuehong
Liu, Yu
Huang, Tung-Shi
author_facet Zuo, Mengdi
Pan, Nengyu
Liu, Quanjing
Ren, Xuehong
Liu, Yu
Huang, Tung-Shi
author_sort Zuo, Mengdi
collection PubMed
description This study aimed to develop novel, biodegradable, antiseptic-loaded and low-cost scaffolds using a direct ink writing (DIW) technique for antibacterial applications. Polylactic acid/cellulose acetate (PLA/CA) mixtures with different composition ratios were prepared, and the effect of CA content on the rheological behaviors of the inks was investigated. The printability of the prepared DIW inks was improved with the addition of the appropriate amount of CA, since the formation of hydrogen bonding 3D network between PLA and CA. As a result, a liquid form ink consisting of majority of PLA and minority of CA which was prepared and printed for the first time through DIW technique. Afterwards, the antimicrobial agent, 1-chloro-2,2,5,5-tetramethyl-4-imidazolidinone (MC) was incorporated into the inks for preventing bacterial infections, which showed excellent stability and effective antibacterial activity against S. aureus and E. coli O157:H7 in a short time. Owning the ease of fabrication and the biocidal property, our 3D printed scaffolds will have a wide range of potential applications in the field of food packaging, communal facilities, medical equipments, and biomedical materials.
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spelling pubmed-90484232022-04-28 Three-dimensionally printed polylactic acid/cellulose acetate scaffolds with antimicrobial effect Zuo, Mengdi Pan, Nengyu Liu, Quanjing Ren, Xuehong Liu, Yu Huang, Tung-Shi RSC Adv Chemistry This study aimed to develop novel, biodegradable, antiseptic-loaded and low-cost scaffolds using a direct ink writing (DIW) technique for antibacterial applications. Polylactic acid/cellulose acetate (PLA/CA) mixtures with different composition ratios were prepared, and the effect of CA content on the rheological behaviors of the inks was investigated. The printability of the prepared DIW inks was improved with the addition of the appropriate amount of CA, since the formation of hydrogen bonding 3D network between PLA and CA. As a result, a liquid form ink consisting of majority of PLA and minority of CA which was prepared and printed for the first time through DIW technique. Afterwards, the antimicrobial agent, 1-chloro-2,2,5,5-tetramethyl-4-imidazolidinone (MC) was incorporated into the inks for preventing bacterial infections, which showed excellent stability and effective antibacterial activity against S. aureus and E. coli O157:H7 in a short time. Owning the ease of fabrication and the biocidal property, our 3D printed scaffolds will have a wide range of potential applications in the field of food packaging, communal facilities, medical equipments, and biomedical materials. The Royal Society of Chemistry 2020-01-15 /pmc/articles/PMC9048423/ /pubmed/35496135 http://dx.doi.org/10.1039/c9ra08916k Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Zuo, Mengdi
Pan, Nengyu
Liu, Quanjing
Ren, Xuehong
Liu, Yu
Huang, Tung-Shi
Three-dimensionally printed polylactic acid/cellulose acetate scaffolds with antimicrobial effect
title Three-dimensionally printed polylactic acid/cellulose acetate scaffolds with antimicrobial effect
title_full Three-dimensionally printed polylactic acid/cellulose acetate scaffolds with antimicrobial effect
title_fullStr Three-dimensionally printed polylactic acid/cellulose acetate scaffolds with antimicrobial effect
title_full_unstemmed Three-dimensionally printed polylactic acid/cellulose acetate scaffolds with antimicrobial effect
title_short Three-dimensionally printed polylactic acid/cellulose acetate scaffolds with antimicrobial effect
title_sort three-dimensionally printed polylactic acid/cellulose acetate scaffolds with antimicrobial effect
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9048423/
https://www.ncbi.nlm.nih.gov/pubmed/35496135
http://dx.doi.org/10.1039/c9ra08916k
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