Engineering hydrogel nanoparticles to enhance transdermal local anaesthetic delivery in human eyelid skin

Herein, we focused on developing the feasibility of nano-enabled local anaesthetic (LA) delivery to anaesthetise the full thickness of eyelid skin. For this purpose a temperature-responsive hydrogel poly(N-vinylcaprolactam-co-hyaluronic acid) (p(VCL-co-HA)) was prepared through aqueous emulsion poly...

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Autores principales: Ozkahraman, Bengi, Emeriewen, Krisztina, Saleh, George M., Thanh, Nguyen Thi Kim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9048424/
https://www.ncbi.nlm.nih.gov/pubmed/35492666
http://dx.doi.org/10.1039/c9ra06712d
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author Ozkahraman, Bengi
Emeriewen, Krisztina
Saleh, George M.
Thanh, Nguyen Thi Kim
author_facet Ozkahraman, Bengi
Emeriewen, Krisztina
Saleh, George M.
Thanh, Nguyen Thi Kim
author_sort Ozkahraman, Bengi
collection PubMed
description Herein, we focused on developing the feasibility of nano-enabled local anaesthetic (LA) delivery to anaesthetise the full thickness of eyelid skin. For this purpose a temperature-responsive hydrogel poly(N-vinylcaprolactam-co-hyaluronic acid) (p(VCL-co-HA)) was prepared through aqueous emulsion polymerization with a Food and Drug Administration (FDA) approved p(VCL) and hyaluronic acid (HA) showing remarkably high LA drug loading capacity.
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spelling pubmed-90484242022-04-28 Engineering hydrogel nanoparticles to enhance transdermal local anaesthetic delivery in human eyelid skin Ozkahraman, Bengi Emeriewen, Krisztina Saleh, George M. Thanh, Nguyen Thi Kim RSC Adv Chemistry Herein, we focused on developing the feasibility of nano-enabled local anaesthetic (LA) delivery to anaesthetise the full thickness of eyelid skin. For this purpose a temperature-responsive hydrogel poly(N-vinylcaprolactam-co-hyaluronic acid) (p(VCL-co-HA)) was prepared through aqueous emulsion polymerization with a Food and Drug Administration (FDA) approved p(VCL) and hyaluronic acid (HA) showing remarkably high LA drug loading capacity. The Royal Society of Chemistry 2020-01-23 /pmc/articles/PMC9048424/ /pubmed/35492666 http://dx.doi.org/10.1039/c9ra06712d Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Ozkahraman, Bengi
Emeriewen, Krisztina
Saleh, George M.
Thanh, Nguyen Thi Kim
Engineering hydrogel nanoparticles to enhance transdermal local anaesthetic delivery in human eyelid skin
title Engineering hydrogel nanoparticles to enhance transdermal local anaesthetic delivery in human eyelid skin
title_full Engineering hydrogel nanoparticles to enhance transdermal local anaesthetic delivery in human eyelid skin
title_fullStr Engineering hydrogel nanoparticles to enhance transdermal local anaesthetic delivery in human eyelid skin
title_full_unstemmed Engineering hydrogel nanoparticles to enhance transdermal local anaesthetic delivery in human eyelid skin
title_short Engineering hydrogel nanoparticles to enhance transdermal local anaesthetic delivery in human eyelid skin
title_sort engineering hydrogel nanoparticles to enhance transdermal local anaesthetic delivery in human eyelid skin
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9048424/
https://www.ncbi.nlm.nih.gov/pubmed/35492666
http://dx.doi.org/10.1039/c9ra06712d
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AT salehgeorgem engineeringhydrogelnanoparticlestoenhancetransdermallocalanaestheticdeliveryinhumaneyelidskin
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