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Dietary Supplementation of Fructooligosaccharides Enhanced Antioxidant Activity and Cellular Immune Response in Broiler Chickens

This study investigated the impact of various concentrations of fructooligosaccharides (FOS) prebiotic on the production performance, antioxidant status, and immune response of broiler chicken. The FOS was used at 0, 0.3, 0.5, and 0.7%. The cycle included 340 broilers distributed into 4 batteries, w...

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Autores principales: Al-Surrayai, Tahani, Al-Khalaifah, Hanan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9048480/
https://www.ncbi.nlm.nih.gov/pubmed/35498745
http://dx.doi.org/10.3389/fvets.2022.857294
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author Al-Surrayai, Tahani
Al-Khalaifah, Hanan
author_facet Al-Surrayai, Tahani
Al-Khalaifah, Hanan
author_sort Al-Surrayai, Tahani
collection PubMed
description This study investigated the impact of various concentrations of fructooligosaccharides (FOS) prebiotic on the production performance, antioxidant status, and immune response of broiler chicken. The FOS was used at 0, 0.3, 0.5, and 0.7%. The cycle included 340 broilers distributed into 4 batteries, with 85 broiler chickens in each battery. There were 5 replicates with 17 broiler chickens each, and the analyses were triplicated. The studied parameters were production performance, antioxidant status, hematological measurements, cellular and humoral immune response, intestinal acidosis, intestinal microbial counts, and volatile fatty acid (VFA) level in the hindgut. Results showed that broiler chickens fed 0.7% of FOS had significantly higher body weight gain than the control group and the groups fed 0.3% and 0.5% of FOS. Supplementing broiler feed with FOS at all levels increased the total antioxidant capacity (TAC) and reduced the malondialdehyde of the sera (P = 0.015 and 0.025, respectively). Liver catalase enzyme in the broiler chickens fed 0.5 and 0.7% of FOS was higher than that of the control group and the group fed 0.3% of FOS (P = 0.001). However, the liver MDA of the control group was higher than that of all the other groups (P = 0.031). The total WBC and heterophils % were the highest after supplementing broilers with 0.7% FOS (P = 0.004 and 0.003, respectively) at 3 wks of age. Conversely, lymphocytes and monocytes were the lowest for the 0.7% FOS group (P = 0.030 and 0.020, respectively). Dietary 0.05 and 0.7% of FOS induced the highest cellular response compared to the other treatments (P = 0.020). Thymus, bursa of Fabricious, and spleen weights were enhanced after FOS supplementation, which indicates a higher specific cellular response. To conclude, FOS prebiotic at all levels can be utilized safely to enhance the antioxidant activity and the cellular immune response of broiler chickens. Using 0.7% of FOS resulted in higher body weight of broilers. Accordingly, this amount of FOS is sufficient to reach the required results.
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spelling pubmed-90484802022-04-29 Dietary Supplementation of Fructooligosaccharides Enhanced Antioxidant Activity and Cellular Immune Response in Broiler Chickens Al-Surrayai, Tahani Al-Khalaifah, Hanan Front Vet Sci Veterinary Science This study investigated the impact of various concentrations of fructooligosaccharides (FOS) prebiotic on the production performance, antioxidant status, and immune response of broiler chicken. The FOS was used at 0, 0.3, 0.5, and 0.7%. The cycle included 340 broilers distributed into 4 batteries, with 85 broiler chickens in each battery. There were 5 replicates with 17 broiler chickens each, and the analyses were triplicated. The studied parameters were production performance, antioxidant status, hematological measurements, cellular and humoral immune response, intestinal acidosis, intestinal microbial counts, and volatile fatty acid (VFA) level in the hindgut. Results showed that broiler chickens fed 0.7% of FOS had significantly higher body weight gain than the control group and the groups fed 0.3% and 0.5% of FOS. Supplementing broiler feed with FOS at all levels increased the total antioxidant capacity (TAC) and reduced the malondialdehyde of the sera (P = 0.015 and 0.025, respectively). Liver catalase enzyme in the broiler chickens fed 0.5 and 0.7% of FOS was higher than that of the control group and the group fed 0.3% of FOS (P = 0.001). However, the liver MDA of the control group was higher than that of all the other groups (P = 0.031). The total WBC and heterophils % were the highest after supplementing broilers with 0.7% FOS (P = 0.004 and 0.003, respectively) at 3 wks of age. Conversely, lymphocytes and monocytes were the lowest for the 0.7% FOS group (P = 0.030 and 0.020, respectively). Dietary 0.05 and 0.7% of FOS induced the highest cellular response compared to the other treatments (P = 0.020). Thymus, bursa of Fabricious, and spleen weights were enhanced after FOS supplementation, which indicates a higher specific cellular response. To conclude, FOS prebiotic at all levels can be utilized safely to enhance the antioxidant activity and the cellular immune response of broiler chickens. Using 0.7% of FOS resulted in higher body weight of broilers. Accordingly, this amount of FOS is sufficient to reach the required results. Frontiers Media S.A. 2022-04-14 /pmc/articles/PMC9048480/ /pubmed/35498745 http://dx.doi.org/10.3389/fvets.2022.857294 Text en Copyright © 2022 Al-Surrayai and Al-Khalaifah. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Veterinary Science
Al-Surrayai, Tahani
Al-Khalaifah, Hanan
Dietary Supplementation of Fructooligosaccharides Enhanced Antioxidant Activity and Cellular Immune Response in Broiler Chickens
title Dietary Supplementation of Fructooligosaccharides Enhanced Antioxidant Activity and Cellular Immune Response in Broiler Chickens
title_full Dietary Supplementation of Fructooligosaccharides Enhanced Antioxidant Activity and Cellular Immune Response in Broiler Chickens
title_fullStr Dietary Supplementation of Fructooligosaccharides Enhanced Antioxidant Activity and Cellular Immune Response in Broiler Chickens
title_full_unstemmed Dietary Supplementation of Fructooligosaccharides Enhanced Antioxidant Activity and Cellular Immune Response in Broiler Chickens
title_short Dietary Supplementation of Fructooligosaccharides Enhanced Antioxidant Activity and Cellular Immune Response in Broiler Chickens
title_sort dietary supplementation of fructooligosaccharides enhanced antioxidant activity and cellular immune response in broiler chickens
topic Veterinary Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9048480/
https://www.ncbi.nlm.nih.gov/pubmed/35498745
http://dx.doi.org/10.3389/fvets.2022.857294
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