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Design, eco-friendly synthesis, molecular modeling and anticancer evaluation of thiazol-5(4H)-ones as potential tubulin polymerization inhibitors targeting the colchicine binding site

In recent years, suppressing tubulin polymerization has been developed as a therapeutic approach for cancer treatment. Thus, new derivatives based on thiazol-5(4H)-ones have been designed and synthesized in an eco-friendly manner. The synthesized derivatives have the same essential pharmacophoric fe...

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Detalles Bibliográficos
Autores principales:	El-Naggar, Abeer M., Eissa, Ibrahim H., Belal, Amany, El-Sayed, Amira A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2020
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9048505/ https://www.ncbi.nlm.nih.gov/pubmed/35496078 http://dx.doi.org/10.1039/c9ra10094f

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